Rebirth of the God-level Xueba

The number of candidate compounds is shrinking day by day

From the first 30 kinds, to more than 20 kinds, then to more than 10 kinds, until the remaining 13 kinds of compounds, the speed of reduction did not slow down.

The compounds that were eliminated in the early stage mainly caused serious reactions in animal experiments. The new drug application rules of various countries are actually similar, but any severe reaction in animal experiments is not allowed to enter clinical trials, which means that a compound has been eliminated.

This is a one-vote veto system, but from the pharmaceutical company's point of view, it is the easiest part.

No additional charges will be incurred for compounds that have already been rejected.

On the contrary, the remaining 13 compounds will continue to generate costs in the process of further animal experiments.

It is more appropriate to describe this process as spending money like running water.

Batches of mice, rats, and pigeons were orally stained with iron, then administered candidate compounds, and then conducted various tests.

The cost of various chemicals and instruments alone exceeds 10,000 RMB per day.

Huang Mao and others did not personally participate in the research of the drug group, but they watched from the side, and they were also frightened.

Seeing that it took them a week to reduce the number of candidate compounds from 13 to 12, Huang Mao couldn't help asking: "Shouldn't animal experiments be done for a year with this kind of progress?"

Because Grace was there, Huang Mao spoke English, and the former replied immediately: "It's normal to do animal experiments for a year."

Huang Mao silently calculated that the average research cost exceeds 10,000 yuan per day. How much is the cost of animal experiments for a year? Definitely more than 4 million yuan!

Although I have known for a long time that developing new drugs costs money, I feel more strongly that the money is flowing away from my eyes.

Huang Mao couldn't help but said, "Huavel's experiments have always exceeded the average speed, so it's impossible for you to really do it for a year."

Grace tilted her head to think for a while, then straightened up and stretched her waist, showing off her beautiful figure, and said: "Internationally, laboratories that develop new drugs have an average of ten medicinal chemists and two to three biologists. experts to participate... We have now, let me do the math, I am a medicinal chemist, Yang Rui and Wang Xiaoyun are two biologists, so, you are right, it is impossible for us to do it for one year, five years. Bigger."

Huang Mao's desire to complain could almost fill the entire laboratory: "Aren't you in a hurry?"

After a long time, Huang Mao choked out such a sentence.

"The lab can't afford a medicinal chemist, so what does it have to do with me?"

"Waiting for five years, wouldn't it mean that you have to waste five years." Huang Mao didn't understand anymore.

"No, five years from now, there may not be other pharmaceutical companies that will do deferiprone. Moreover, since we have started animal experiments, we must complete them. Otherwise, it is also a disservice to other pharmaceutical companies." Responsible, irresponsible to thalassemia patients." Grace's thinking circuit is very strange.

Huang Mao didn't react for a long time, and asked, "Why?"

"Are you asking..."

"The irresponsible part."

“Grace’s point is that if we stop doing animal experiments halfway, other pharmaceutical companies may think that our animal experiments are in such a bad situation that they will completely abandon the deferiprone project.

Listening to their conversation, Yang Rui interjected, and said, "We are in a good state at the moment. No pharmaceutical company will give up the project at this stage. Therefore, unless we encounter other force majeure, animal experiments will definitely happen." If it is not completed, other companies and even the FDA will consider this situation. In case of lawsuits, lawyers will definitely get to the bottom of it. "

Huang Mao understood, and changed it this time, and asked, "Is it good to finish it?"

"Projects that have passed animal experiments can already be sold at a good price."

"How to sell?"

"There is a special market." Yang Rui actually didn't know very well, where did he have the opportunity to play such a game of mergers and acquisitions before.

Huang Mao opened his eyes wide and asked, "Is it expensive?"

"It won't be too cheap, it's just the expense." Yang Rui curled his lips.

Huang Mao also realized in an instant that the experiment conducted by Huarui Laboratory in a relatively cheap way will cost 20 million yuan in five years. If a foreign company hires 10 medicinal chemists and two or three biologists, one The annual salary has to go out to millions of dollars, not to mention other costs.

"It's just too long." If it takes five years to earn back tens of millions of yuan, Huang Mao doesn't think the income is too high. There are too many domestic factories with annual profits of one million or ten million. The expenses are also more than one million US dollars, especially in the ongoing lawsuit, the fees charged by American lawyers are skyrocketing, and 20 million yuan is not enough to fill in the holes.

Thinking about it this way, when it was time for lunch, Huang Mao deliberately sat next to Yang Rui, smiled at Grace at the same table, and said, "Yang Rui, otherwise, don't spend all your time on deferiprone."

"Why?" Yang Rui asked strangely.

"Five years!" Huang Mao sighed, and said, "Yang Rui, don't blame me for speaking harshly. Don't look at your current high efficiency and good grades, and think that you will always be like this in the future. Impossible, you I am 20 years old this year, and this is the age with the best results. Why does our country have a juvenile class? It is to make scientific researchers have a longer scientific research life, and start research at the age of 20. Like you, the high-yield period can last until the age of 30. If you are 35 years old, if you are more powerful, you can continue until you are 40 years old. In these 20 years, you will have twice as much time as an ordinary scientific researcher."

After a pause, Huang Mao said again: "Think about it, you'd better do 20 years of scientific research, and you want to spend five years doing deferiprone? I'm not saying that deferiprone is not important, but the current animal experiments , I can do it, Lao Tu can do it, Wang Xiaoyun can do it too, why do you waste your golden time on this, how many things can you do in five years?"

Yang Rui was taken aback by Huang Mao's words.

In his drug group, there are only Wang Xiaoyun, Wei Zhenxue, and Grace who volunteered. In fact, it is because the animal experiments are relatively simple, and he does not want to waste the time of the calves he has finally acquired.

People like Huang Mao and Li Wenqiang are all capable of publishing cell-level articles in the future, so why use them for simple physical work.

But Yang Rui forgot how much time he had to spend on this.

After careful calculation, the entire animal experiment took only two weeks, but for a scientific researcher, two weeks is a lot of time.

"Take it as a vacation and change your mind." Yang Rui smiled and explained to himself and Huang Mao at the same time.

Huang Mao was dumbfounded.

Wei Zhenxue, who was sitting not far from this table, had been eavesdropping with his ears up—and only he could do such a thing—now he coughed and said: “People are different, some people are on vacation. It’s going outside to play, some people go home to sleep on vacation, some people go on vacation to pull the spine of a mouse..."

"I didn't even move a single mouse." Yang Rui explained again.

"I made a mistake. Some people like to watch people pull the spines of mice on vacation." Wei Zhenxue laughed, consciously saying it perfectly.

Yang Rui was speechless, and suddenly wondered if he had a tendency to pervert. After thinking about it, Yang Rui thought again, it's not a big deal if it's not abnormal or biological.

"I'll take another week's vacation. If it doesn't work, I'll consider changing it." Yang Rui stood up as he spoke, patted Wei Zhenxue's neck twice, and then stood still.

Wei Zhenxue only felt goosebumps all over his body, and the warmth on the back of his neck was chilling.

Yang Rui tapped Wei Zhenxue's neck bone with his thumb, thinking about how to speed up the progress of animal experiments.

As a simple permutation and combination elimination experiment, the speed of animal experiments can only be changed according to the amount of resources in many cases. There is very little room for technology to play, because no matter how good the technology is, you can’t see it. Changes in a chemical compound in the human or animal body.

If you don’t try it, who knows the effect of the compound, whether it will be metabolized or enriched, whether the metabolic pathway is as expected, whether the metabolites are beyond imagination...

Yang Rui knows.

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