Rebirth of the God-level Xueba

Yang Rui quickly set up a drug research team in Huarui's laboratory, and selected Wei Zhenxue to cooperate with him, and added two scientific research teams, even if he set up a grass-roots team for deferiprone. Great God Ring (.. no pop-up ads)

Including inside Huarui Laboratory, everyone is not optimistic about Yang Rui.

If it weren't for the great prestige he had accumulated over the past year, the colleagues in Huarui's laboratory would have opposed Yang Rui's decision just like Xu Zhengping did.

During this time period, objection is the normal response.

Pharmaceutical research itself is a very professional field. In original drug companies, those researchers who spend half their life on a single drug are basically god-like existences in the subdivided specialization field. After Reagan's bill, universities and research institutions at all levels, some experts and scholars who have switched from academia to industry, have greatly enriched this field, and also raised the threshold of pharmaceutical research to an infinitely high level.

Not to mention grassroots teams, even if they spend hundreds of millions to form a team, they dare not call it a dream team in the field of drug research.

Scholars in the academic world naturally look down on researchers in the industrial world, but it is true that the Nobel Prize winners in the industrial world are not much less than those in the academic world, especially between the 1980s and 1990s. It is popular for academics to change jobs, because the big pharmaceutical companies offer too much salary, often tens of millions of dollars, and tenured professors with an annual salary of 70,000 dollars can hardly hold themselves. In addition, those 40-year-old Professors who have won almost lifetime achievement awards at the age of 50 do not have any pursuits in the academic world, and many people have plunged into the ocean of industry and even business circles. Wealthy Marriage and Sweet Love

However, super pharmaceutical companies like Zeneca have never been afraid of the challenges of small pharmaceutical companies. Their biggest magic weapon is acquisitions, and at a price of 35 million or even 100 million US dollars, all promising small pharmaceutical companies Pharmaceutical companies are in the bag - even if they can't, they will buy out the products of small pharmaceutical companies directly.

For example, if Yang Rui did not intervene in the technology of Sister Company, it would be resold at a price of 300 million U.S. dollars, and several Nobel Prize winners in Sister Company are also very happy with the money. After I improved my life, I went to work in other companies...

All in all, modern pharmaceutical companies are the companies with the highest requirements for technology and the companies that need the most technology. In contrast, the industry outside the pharmaceutical company has been basically separated from the academic world. The world cannot extricate itself, the metallurgist is making materials, the material maker is tossing microscopic crystals all day long, the wafer maker is checking hygiene, computer professors don’t know what to do for a long time...

Only the research and development of pharmaceutical companies can use Nobel Prize-level scholars in the whole process from theory to production. In other words, the world's top technology can be directly used in end products. Super Auction House[.. so many good-looking j

This process is naturally extremely complicated, and sometimes it is carried out by luck. For example, deferiprone is an iron chelator, but no research team of a pharmaceutical company has ever thought of saying, "I will find an iron chelator." He can only obediently wait for an iron chelator to be discovered, and then consider how to make it into a medicine.

Only after deferiprone is discovered will there be a chance to make medicines for deferiprone.

This is also the first step in the pharmaceutical process, the selection of drug targets.

After the target, there are more troublesome researches on drug synthesis and pharmacokinetics.

In order to pass the inspection of the national drug supervision bureau,

All steps must be carried out step by step, and strictly recorded. If you go too far, you will face the situation that the clinical trial will not be approved. Unless the researcher uses himself to do the experiment, otherwise, the development of a new drug will be considered as over. up. The Record of Flying Ascension

Yang Rui actually didn't know the specific process, but he was not in a hurry.

He is not a person with a background in medicinal chemistry or drug synthesis. It doesn't matter if he doesn't understand the process. His focus now is to synthesize deferiprone first, and then see if the effect is good. If the effect is good, he can find someone else in time. .

Of course, with Yang Rui's self-confidence, he asked Li Zhangzhen to find someone at the same time.

Others don't understand Yang Rui's fanciful self-confidence, but Wei Zhenxue doesn't care at all. He just needs to do experiments. The more sophisticated the experiments, the more Comrade Wei Zhenxue likes them.

The two seemed to be back in West Castle High School again, no matter what other people said or did, they just kept their heads down and did their own experiments.

"The fourth deferiprone experiment was a direct reaction between 3-carboxy-2-methyl-4-pyrone and methylamine..." Yang Rui made a record of the experiment and started the experiment immediately.

Wei Zhenxue was helping at the side, and said in his mouth: "You can't do it like this, but if you can do it directly, they have already synthesized iron ketone."

"It's because the predecessors haven't made too many attempts. When deferiprone was discovered, they only did research on iron chelation, and did not study the synthesis of deferiprone carefully. Lei Wu" Yang Rui shrugged and said : "The previous method was used, and the yield was too low."

"It's not just too low, I think he doesn't know how to synthesize compounds at all." Wei Zhenxue laughed and said, "The yield is less than 1%, and it's not pure enough. It's hard to know how many people will be poisoned to death when it's made into medicine. It's highly toxic, the name How about it?"

Yang Rui didn't say a word, still looking at the test bench.

Wei Zhenxue boasted: "It's not me, I am a chemistry major, and I have published many papers when I was doing coal chemistry. I don't know how good it is, but the method he used is really not good. The one you use is even worse, why don't you listen to me, let's start with the protection of the carboxyl group, find a way to methylate it, and then remove the protection group, it is estimated that we can get deferiprone..."

"It's also a way." Yang Rui was noncommittal.

"My method is more reliable." Others would not talk to Yang Rui like this now, only Wei Zhenxue, who has not changed his original intention for many years.

Yang Rui smiled and said: "It is true that it is more reliable, but it is also more troublesome. Let's first consider whether the simple method can be done or not, and then consider the complicated method."

"You said it the other way around."

"I can't control so much, let's do this first." Yang Rui replied casually.

The method Yang Rui is using now is a chemical synthesis method invented in 1994, which is the cheapest synthesis method.

Needless to say, it was a substitution method in the 1960s, and basically cannot be used in industrial production. As for the method proposed by Wei Zhenxue, if there are a few more changes, there is a chance to synthesize feriprone, but Yang Rui is not going to use it.

Because he only needs one way to produce deferiprone. As a researcher who is not very familiar with chemical synthesis, it is normal to get a simple and convenient chemical synthesis method by luck. It is impossible.

Therefore, Yang Rui was in place at the first time, and simply used methylamine for direct reaction.

However, according to the normal chemical thinking, direct reactions such as primary formation have never been easy, and in the words of scholars, they are unreliable.

Generally speaking, everyone is more inclined to find a simple way to produce it first, and then gradually improve it. Like coenzyme q10, Yang Rui has modified it for three times, and it has not yet been in place. Zeneca is also very satisfied.

Unfortunately, deferiprone is not as profitable as coenzyme q10. Yang Rui is more inclined to establish a pharmaceutical company through this work. Therefore, the focus of his work is clinical trials and application processes, not pharmaceuticals. process.

Therefore, after several wrong experiments, Yang Rui couldn't help himself, and he was even more lazy to upgrade step by step, so he took out the technology that a certain scholar came up with 10 years later, and let those gas and liquids in his own experiment Wander over the table.

Wei Zhenxue shook his head again and again, and said: "Yang Rui, I didn't say that, you are indeed a genius biologist, the strongest I have ever seen, and Peking University probably can't find anyone who is better than you. But biology and chemistry are different. Are you a biologist? Biologist, regeneration genius, you are also good at biology, but I am a chemist, synthetic chemistry should listen to me, right?"

"Let's do it first..." Yang Rui perfunctory Wei Zhenxue.

"If you don't listen to me, why did you come to me." Wei Zhenxue said angrily, "If you don't listen to me, I'll go back."

With that said, Wei Zhenxue was about to leave.

Yang Rui was stunned for a moment, and said: "I asked you to be my assistant, not to ask you to be my uncle."

"Is that so?" Wei Zhenxue paused in leaving.

"certainly."

"You don't want me to help you synthesize deferiprone?"

"As an assistant, you are helping."

"That's it... I thought you asked me to take charge of the work." Wei Zhenxue turned his ankle, returned to the test bench, and said, "Then I will be an assistant."

"Originally." Yang Rui didn't know whether to laugh or cry. He hadn't experienced Wei Zhenxue for a while, and when he met Wei Zhenxue for the first time, he didn't quite get used to it.

However, Wei Zhenxue has never changed. He re-read Yang Rui's experimental records, his head shook more and more, and said: "Even if you don't let me take charge of the work, treat me as an assistant, I have to say, you It can't be done like this!"

"Let's wait and see." Yang Rui did it a few times before knowing that he couldn't do it. It can be regarded as a practice, and he is familiar with the equipment and test methods in this area. This time, he used simple direct synthesis again, which is more effective. confident.

Wei Zhenxue was also overwhelmed by the surging self-confidence, and vowed: "I will wait and see, if you can directly synthesize ferritone from methylamine, I will twist my head off and kick it for you."

Yang Rui couldn't help laughing.

Huang Mao, Tu Xian, Li Wenqiang and others in the laboratory also passed by curiously when they heard about the bet.

Wei Zhenxue inexplicably felt the chill on the back of his neck.