Rebirth of the God-level Xueba

At the end of the meeting, Xu Zhengping finally understood Yang Rui's thoughts, and said in astonishment, "It's really wrong for us to make deferiprone."

Biologists do make medicines, but this does not mean that any biology scholar can do medicine research, let alone make medicines as they make medicines.

Yang Rui's ion channel laboratory, normally speaking, belongs to the foundation of basic biology, and has already been based on the ion channel of cells. It is almost the lowest biologically active substance that humans can access at present. What else? Base.

If in a few years, targeted drugs rise, the biologists in the ion channel laboratory are really suitable for drug research, and it is no problem to transfer to the industry to earn some money.

But right now, the research in the ion channel laboratory is too far ahead of the drug research. In addition, the laboratory may not be willing to lay down and do work in the industry. As far as Xu Zhengping himself is concerned, he earns a similar salary anyway, so why not stay in the promising laboratory of Peking University and do promising basic research. It is very stressful to write papers. If you take a step slower, the people behind If you catch up, your previous efforts will be in vain. When you turn around two or three years later, you may have become the rear when you once occupied the leading position.

Choosing to do scientific research is to choose a lifetime of competition. A slightly ideal scientific research worker, starting from the third year of high school, is basically in the state of the college entrance examination every year. The top people are fine, and the rest can be filled with scientific research dogs. If not, a few scientific research apes will do.

Only guys like Yang Rui have the energy to think about doing other things.

However, Yang Rui also understood Xu Zhengping's thoughts, and only said: "Let's go to the doctor who spoke before to see what the specific situation is like."

He thought to himself, if the ion channel laboratory can't make drugs, then Huarui laboratory can do it well.

Although it is not a profitable project, it should be able to make money in the end. After all, Yang Rui doesn't have to worry about the most time-consuming research and development process, and he doesn't have to worry about not being able to produce results, and these parts are the most risky. As for clinical trials, it is true that it consumes energy and time, but it is mainly troublesome. The level of drugs is acceptable, and clinical trials are always acceptable. There are so many countries in the world, and it is not necessarily necessary to sell them globally.

In fact, Yang Rui doesn't care even if he doesn't make money.

The ultimate goal of his establishment of Huarui Lab is for freedom, not just the financial freedom of simple personal enjoyment, but also the pursuit of ideal financial freedom.

Do any experiment you want to do,

Do whatever research you want, this is Yang Rui's ideal—silver chloride, platinum rods, throwing a piece of pure sodium to watch the explosion, making tea with four nines...

There is no need for any explanation for rashly pulling Huarui Laboratories to make a drug that does not make much money. It is nothing more than money and willfulness.

"I want to see the patient's condition." Yang Rui looked around and said, "It happens to be in the hospital. Ask if you can take a look."

"Okay." Xu Zhengping had no objection. As the deputy director of the ion channel laboratory, he wanted to support the director Yang Rui. He turned around and asked Wang Sisheng, "Xiao Wang, do you know the doctor who spoke just now?"

Wang Sisheng thought to himself, "How could I know that?" He turned his head and said with a smile, "I'll ask."

After a while, Wang Sisheng asked someone to come over and said: "It happens to be a doctor from Xiehe Hospital. His name is Yong Xiaodong. I gave Director Yang's name, and he immediately agreed. He is now in the inpatient department and will send someone to pick us up later."

After a total delay of less than half an hour, Yang Rui met Yong Xiaodong who was waiting there on the first floor of a certain building in the inpatient department.

"Director Yang, Director Xu, Comrade Wang..." Yong Xiaodong shook hands with the three enthusiastically, and then greeted the three scientific researchers who followed behind, and introduced as he walked: "My current work focuses on thalassemia. I am very happy that you are interested in knowing about the disease, as there are too few people willing to know about this disease."

Soon, Yang Rui knew the reason why people didn't want to know.

That's horrible.

If cancer patients undergoing chemotherapy and hair loss is a cosmetic change, then thalassemia major can be said to be a cosmetic transformation.

The deformed bones due to compensatory hyperplasia transformed the patient beyond recognition, but most of the patients with severe diseases were children...

Seeing a child whose face, abdomen, legs, and arms deformed at the most elementary school age, even the oldest Xu Zhengping couldn't stand it anymore, and couldn't help asking: "Why are they all so small? "

"Thalassemia major is a disease of premature death." Yong Xiaodong whispered.

The implication is that the older ones are dead.

Xu Zhengping shook his head and said, "I remember you said in your report today that the average age is between 15 and 20 years old, here are all elementary school students..."

In fact, it’s not just elementary school students. Most of the children are only below the third grade of elementary school. There are also many children in kindergartens who don’t even understand what happened...

"Generally, those who are sent to our hospital are those whose parents still have a glimmer of hope, and those who cannot be cured by the age of nine or ten usually go home." Yong Xiaodong said in a low voice: "People with thalassemia in the north are not There are many, mainly in the south, especially in Guangdong, Guangxi, Yunnan and Guizhou. There are many carriers of the thalassemia gene and there are many patients. When they come to the capital, the cost is also high. If there is no obvious improvement, most of them will choose the hospital at home. Or there is no treatment."

"Didn't insist on treatment?"

Yong Xiaodong smiled wryly: "We can't even talk about treatment now. Apart from blood transfusion and deferoxamine transfusion, there is no other treatment plan. Moreover, the cost is also very high."

Not only does it cost a lot, severe thalassemia requires long-term blood transfusions and infusions, and when he is a little older, hemoglobin has dropped, so regular blood transfusions are required. The time is long, the dosage is large, and the treatment of complications is a daily expense. Dou Jin.

Yang Rui turned his head casually, and he could see a decadent father, a sad mother, a pained parent, and a numb child.

The disease that requires blood transfusion once a month at most in less than half a month, as well as the iron-removing injections with similar frequency, and the dramatic changes in appearance are not enough to make children feel the beauty of life.

Even if ironone is developed, I am afraid that life will not be good.

However, the pressure will be reduced a lot.

Yang Rui thought about it and asked: "If an oral iron-removing agent is developed, will it help?"

Yong Xiaodong's eyes lit up, and he asked, "Has any pharmaceutical factory produced oral iron-removing agents?"

"Not yet, I want to find out first."

"If there is an oral iron-removing agent, it will definitely help, at least it will allow these families to persist for a few more years." Yong Xiaodong said unbearably: "Although the result is still the same in the end, it should still be different. .”

If you have been a doctor for a long time, you are usually not too emotional, but when you face a group, your feelings will also be enriched.

Looking at his expression, Yang Rui couldn't help comforting him: "Although the end result is the same, it is also important to have a different process. We are not gods and cannot change the world. No matter how critically ill, there is still a big difference, at least you can see the world, and the first ten years of your life can be easier."

"And there are patients with thalassemia intermedia, who can achieve even more changes."

Yang Rui nodded, and introduced the hydroxypyridone compounds that hider researched, saying: "I don't know much about deferiprone, but as far as I know, the structure of deferiprone is electrically neutral, and it has a certain Lipophilicity and small molecular weight, which means..."

"It can be absorbed in the gastrointestinal tract!" Yong Xiaodong immediately responded.

Yang Rui nodded: "And it can penetrate the tissue cell membrane. It is not yet known how it will behave in the cell, but imagined from a better direction, it should be able to chelate iron atoms in the cell."

Normal infants and young children must pay attention to iron supplementation when eating milk powder, but for children with thalassemia, every reduction in iron means that life can be prolonged for a period of time and a certain quality of life can be improved.

Yong Xiaodong took two quick steps excitedly, but after a short while, he stopped again and said angrily: "It's a pity that no pharmaceutical factory produces the oral iron-removing agent you mentioned. Even if the basic conditions are available, foreign pharmaceutical companies are still unwilling to develop it. .”

The reason why we only talk about foreign pharmaceutical companies is because Chinese pharmaceutical companies simply do not have the ability to create original drugs.

The pharmaceutical companies in the world are divided into two categories, one is the original drug company, including the familiar Johnson \u0026 Johnson, Pfizer, Bayer, or Zeneca and so on.

In addition to original drug companies, there are also professional generic drug companies.

Generic drug companies are companies that carry out generic production after the original drug company's drug patent expires. For example, Viagra is owned by Pfizer, but when Viagra’s patent expires, Jin Ge can be sold, and it is not necessarily cheap. On the contrary, it saves the unpredictable drug development process and extremely difficult clinical trials, which is equivalent to reducing the risk of drug development. The cost of hundreds of millions of dollars saves an average of fifteen years of research and development time.

In European and American countries, the number of generic drug companies is dozens of times that of original drug companies, and the scale and strength of many companies cannot be underestimated—if you want to copy others, you must have a certain level.

Some generic drug companies are also very large, such as Diva Pharmaceuticals in Israel, Sandoz in Germany, and Mylan in the United States. They are all large pharmaceutical companies with annual sales of billions or even tens of billions.

In China, however, original drug companies basically do not exist, that is, the scale of generic drug companies is very small. Except for some commonly used hot products, medicines produced in foreign countries in the 1960s are too late to be imitated in China.

Under such circumstances, it is naturally very unreliable to count on domestic pharmaceutical companies.

Yang Rui patted Yong Xiaodong and said, "Let me figure out a way."

"Can you think of a way?" Yong Xiaodong clearly expressed disbelief.

Wang Sisheng couldn't help but said: "Our Director Yang has a very good relationship with Zeneca in the UK."

Yong Xiaodong's lips moved, but he still couldn't help saying: "It's useless, the British don't suffer from thalassemia."

"We don't rely on the British, we rely on ourselves." Yang Rui looked solemnly at the bed next to him. The child on the bed was lying on the infusion pitifully. He didn't know whether he was asleep or awake. His chest and legs were bony. , The belly swelled high, and the mother sitting on the side lowered her head. When the doctor came, she just looked up, and then lowered heavily.

Xu Zhengping followed Yang Rui's gaze, took a breath, and hurriedly said: "Director Yang, this matter needs to be discussed in the long term."

"I know."

"Director Yang, Yang Rui, making medicine is a research in biochemistry. Let's start from scratch, how can we have time!"

"Of course we have to make it as soon as possible." Yang Rui looked away and sighed inwardly, but he secretly made up his mind to create his own original drug company.

Even if it doesn't make money, even if it loses money, the pharmaceutical company should be established first.

Any scientific research product has never been produced without input.

The biological and pharmaceutical industries are even more typical.

China needs to have its own original drug company.

If it’s industrial or agricultural products, it doesn’t really matter whether you have your own factory or not. International division of labor is a great cooperation. You produce precision machine tools, and I produce refrigerators. I need your precision machine tools, and you can’t use electricity. Refrigerator bar.

Even agricultural products, in fact, are nothing special. The US government will not deliberately starve the Chinese people, and there is no need for that. It is just that the price is higher and the quality is lower.

But medicine is really different.

As Yong Xiaodong said, the British are not free from thalassemia. Therefore, it is difficult for British pharmaceutical companies to have the urge to make thalassemia drugs. The reason why it is difficult is that India is the traditional market of the UK, and The South Asian region where India is located is a severe area of ​​thalassemia, so in the end only Indian companies insisted on producing deferiprone.

However, Germany, France, Italy, Spain, or Norway and Denmark, which are also in Europe, do not even need to add adjectives such as "difficult". It is completely impossible for them to make thalassemia drugs, because they do not have any For patients with thalassemia, instead of spending more than ten years researching the drug and taking the risk of going abroad for clinical trials, it is better to choose a common disease in the country to overcome.

In the final analysis, the common genetic diseases of the native people need the domestic pharmaceutical companies to overcome them.

This will also be the cold reality faced by all countries and nations in the post-gene era.

If you don't invest in scientific research, you don't even have a reference for copycats.

If the country is unwilling to invest, people from other countries may donate sympathetically, but they will never donate a top-notch scientific research team for fifteen years, which is the same research funding as a bottomless pit.

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