Rebirth of the God-level Xueba

Chapter 139 Research and Development Chain

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Yao Yue, who put on light makeup, came out of the hibiscus with clear water, and her sweet and fresh smile gave Yang Rui a little surprise.

Yang Rui has always been unable to tell whether a woman has makeup or not. Except for the nightclub-style heavy makeup, he, like most men, does not know the details of a woman's face to know whether she looks good or not. That's why girls have the meaning of makeup.

However, girls in the 1980s obviously didn't understand this. Just two years ago, the "Iron Lady" was still being promoted everywhere in the country. The so-called "use women as men and men as animals" was definitely a compliment before the 1980s. The imperial literati often wrote "who A Mulan-style reportage that says women are inferior to men.

With the reform and opening up, women's aesthetics began to awaken. Handmade sweaters, floral shirts, red skirts and flared trousers gradually appeared, but there are still very few people wearing makeup, especially in prefectures and counties. I have already put on makeup, and when I get married, I put on some blush, which is already considered heavy makeup.

Yao Yue is a girl from a big city. Although the conditions are poor, she is still youthful and invincible. She dresses up carefully and easily highlights her bright and lovely image as a girl.

For Yang Rui, who hasn't seen a TV movie for a long time, and hasn't even seen a fashion poster for several months, the impact of the real 3D beautiful girl is far better than the 2D animated beautiful girl.

Even worse than Yang Rui was He Cheng, an experimental assistant.

He Cheng, who grew up in a township, only had space for activities around Xibao Town, and his only chance to see beautiful women was in movies.

However, how can hazy township film movies be compared with real beauties.

He Cheng glanced at Yao Yue's calf under the long skirt, and had the urge to spray nosebleeds. The experiment he was doing was completely messed up.

"Beautiful!" Yang Rui praised naturally.

In terms of appearance, he still has a bit of self-confidence.

It was Yao Yue who blushed first, and lowered her head carelessly and said, "Yesterday's clothes were dirty."

The answer was a bit inexplicable, and I didn't know what I was explaining.

In fact, Yao Yue felt that what she was wearing was a little too ostentatious.

The red one-piece dress under the white coat is as eye-catching as a catwalk in a world of green military uniforms and gray cloth clothes.

As far as the sense of the times is concerned, it is equivalent to a certain star wearing the dress worn when shopping on Avenue des Champs-Elysees in Paris, walking in Tangjiabao Wulipu.

But what Yao Yue said was also true. When Yao Yue came to Xibao Town, she only brought such a change of clothes. As for why she brought her most beautiful clothes, which she bought from Shanghai, this kind of little daughter's mood is not worth mentioning.

Yang Rui thought it was very good-looking, in line with his own aesthetics, so he naturally looked around her,

He smiled and said, "What should I do? Wearing a white coat outside is a waste, and if you don't wear a white coat, it will get dirty easily."

"When my clothes are dry, I'll change them back." Obviously, Yao Yue had never received such a direct compliment, and she was more shy when she was happy.

Lu Zhi nudged him with his elbow, and said, "What do you do in exchange? You don't stay in the laboratory all day, you still have to wear your own clothes when you go out."

"Don't talk about clothes, what kind of experiment are you doing? Can I help?" Yao Yue was embarrassed and didn't want to go on.

Yang Rui didn't have any experience in love, so he failed to seize the opportunity to chase after it, and his train of thought was led astray, saying: "We are doing verification experiments to test the authenticity of several Japanese papers."

Yao Yue saw that he was talking about the experiment, and immediately felt a lot more relaxed. Seeing the experimental preparations ahead of He Cheng, he picked it up and looked at it, and said, "You told me about plant extraction?"

"Yes, Japan's land is small, and animal husbandry has never been very competitive. Therefore, their scientific community has always disliked the tissue extraction method. Out of consideration for the interests of the pharmaceutical industry, while developing the tissue extraction method, they are also actively trying plant extraction and microbial cultivation. There must be some progress in both chemical synthesis and chemical synthesis." Yang Rui gave a general explanation. In the field of biopharmaceuticals, Japan has seized the opportunity and developed very fast. Some biological products, such as insulin, etc., have occupied the global market. The same is true for coenzyme Q10. Japan was the first to make efforts in this field. At the same time, it tried plant extraction, microbial cultivation and chemical synthesis. In the 1980s, it selected a half plant extraction and half chemical synthesis method, and gradually implemented microbial cultivation in the 1990s. In this way, the money spent is golden mountains and silver seas. In this regard, China in the 1980s could not even afford admission tickets.

However, the cost of biopharmaceuticals lies in research and development. For Yang Rui, who already has the answer, it is not so expensive to replicate once.

Of course, not expensive is relatively speaking. His laboratory spent more than 30,000 U.S. dollars, plus 20,000 U.S. dollars in cash. Many investments are not recovered.

This is the last time that Yang Rui was lucky enough to catch up with the plant extraction method. If it is the microbial culture method, there is no need to try it. A good fermenter can sell for tens of thousands of dollars, and a string of fermenters can cost hundreds of thousands of dollars. Yang Rui received this year's dividend, which is not enough to copy it once.

As for the pure chemical synthesis method, which should be the most advanced and the lowest cost, until 2014, there was no mature industrial production method, and large international pharmaceutical companies invested tens of millions of dollars in this, which is an invisible bottomless pit.

Although Yao Yue and the others started to help in the lab, they didn't know much about R\u0026D itself. Yao Yue looked at it for a while, then asked curiously: "Is it possible that Japan has already achieved results? Are we going to do research on localization?"

On the contrary, Yang Rui was surprised: "Why must Japan have achieved results, so we copied it?"

"Localization is different from copying." Yao Yue said impatiently, "It is to fill the gap in the country and save foreign exchange for the country..."

"That's not plagiarism. The research on localization is the most time-consuming and money-wasting project. This is not military equipment." Yang Rui said in his heart: Even if I plagiarize, I will not copy existing patented technologies. What's the meaning.

Lu Zhi also turned her head to look at the experimental preparations. She didn't quite know what experiment Yang Rui was going to do, so she asked, "Do you want to conduct experiments based on Japanese research? This is more difficult."

In the hearts of Chinese people, foreign research is naturally advanced, and it is naturally extremely difficult to do research on a foreign basis.

This is actually not wrong.

Experimental science must rely on experimental equipment to complete. Experimental science without experimental equipment is a grassroots. Maybe, occasionally, there will be one or two brilliant ideas to replace repeated machinery and equipment. However, if you want to spend a lifetime This kind of person should not engage in experimental science, but should sing about little stars.

Foreign laboratories are equipped with advanced equipment, and the scope of their research is wide. If one wants to do research on the basis of them in China, it is best to have more advanced equipment, or at least similar equipment.

This is like the gatekeeper Leeuwenhoek, a Dutchman with no formal education, when he polished an excellent lens and saw the world of microorganisms, even though his article "Leuwenhoek uses a self-made microscope to observe the skin , Meat, and Certain Records of Bees and Other Insects" was so crude that the scientists of the Royal Society had to publish it in the Journal of the Royal Society, having confirmed it with the help of Leeuwenhoek's microscope .

No matter how smart other people are, no matter how nice their singing is, without a microscope with a magnification of two to three hundred, he is not qualified to do research on the basis of Leeuwenhoek.

The development of modern industry has raised the threshold of science rather than lowered it. Catching up with developed countries was a difficult and even hopeless task for the Chinese in the 1980s.

If Lu Zhi had worked in a university laboratory for three or four years, he would never have asked such a question.

However, Yang Rui's answer is yes: "We want to avoid the technical barriers of Japanese pharmaceutical companies. Well, they can't be called barriers yet, they are just stumbling blocks. No matter what, we have to use our own way to complete the process." Some basic research, this is the basis of the plant extraction method, and then, on this basis, we need to establish our own technical barriers to the plant extraction method. The work is very heavy and there are very few researchers, so we will now let's start."

As Yang Rui spoke, he set up tasks.

If it is a large pharmaceutical company in Europe and the United States, it will not do this. They will first use the research results of Japanese pharmaceutical companies, regardless of whether they have technical patents, and then, after the birth of a profitable technology based on this patent, they will reverse the search for a solution. It is naturally good to find a solution. Make money happily. If you can't find a solution, then you will flagrantly infringe upon the other party and send dozens of lawyers to accompany the other party in the lawsuit every day when the other party sues, while selling medicine happily.

Small and mid-sized pharmaceutical companies fear the giant vulture. Because this kind of patent lawsuit usually lasts for several years, and a team of dozens or hundreds of lawyers may spend tens of millions of dollars a year. Small and medium-sized pharmaceutical companies will go bankrupt before the court pronounces a verdict. Only large pharmaceutical companies Only then can I afford it.

Yang Rui is not a pure researcher, he wants to make money through this technology, and he only has an ultra-small biological research and development team, so he must first solve the other party's technology patents, and then establish his own technology patents, and then take all the patents and ask for a price .

And all these steps and processes need to be supported by experiments and papers.

If there is no process, just get a result, except for those super-large Big Macs, the Food and Drug Administration of any country will not pay attention to it. Drug companies are also not making good bids.

Even if it is only a difference in the extraction method, a strict research and development chain must be established.

This is a huge test for Yang Rui, who is severely underfunded, and he can only comfort himself, fortunately, this is the meta-era of biotechnology.

...◇(to be continued)

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