My Life Simulator

"Come on, let's go to the Cancer Institute!"

After reading Lu Li's paper, Professor He hurriedly got up, "Let's go to the laboratory to verify it."

If it is a paper on the nature of irrigation, there is naturally no need for verification. Lu Li's research value is extremely high, and it can even be said to be a pioneering and great achievement. Naturally, it must undergo comprehensive and detailed verification.

So, together with Lu Li, Professor He hurried out of the office and went all the way to Fudan Cancer Institute.

"Lao Guo, Lao Guo, come on!"

Walking into the Institute of Oncology, Professor He held up the thesis materials in his hands and shouted all the way.

"I'm here! I'm here!"

Professor Guo's head appeared from the door of his office.

Seeing Professor He running over excitedly, with Lu Li behind him, Professor Guo quickly asked, "Old He, why are you yelling so much?"

"Lu Li has published the research results, quickly organize the staff to verify it."

Professor He's footsteps are flying, shouting as he walks.

Research results?

Hearing Professor He's words, Professor Guo was stunned for a moment, and looked at Lu Li with a bit of horror.

Does this work?

It has only been more than two months since the last release of the improvement plan for CAR-T technology? Results again?

The busy graduate students and doctoral students next to them also stopped one by one and looked at Lu Li one after another, thinking to themselves: Why are you producing results again?

"Old Guo, come and see!"

Professor He's face was flushed, and he walked like a fly. He walked into Professor Guo's office in a few steps, and shoved the thesis materials into Professor Guo's hands, "Quick, organize the verification."

"What are you panicking about? I'll take a look first!"

Professor Guo was still calm, ignored Professor He's shouting, and read the thesis materials.

"The application of gene editing technology for T cells and B cells in CAR-T technology."

application?

Seeing this keyword, Professor Guo's eyes twitched a few times. Dare to write the application on the title, is it... Lu Li is sure that this technology has matured?

CAR-T technology is mature, what is the concept?

As the scientific research leader of the Cancer Research Center, how could Professor Guo not know about CAR-T technology?

This new technology, which is still in the exploratory stage, once it matures, it means that it has found a special drug for cancer treatment, and found the most reliable technology for cancer treatment.

From a clinical point of view, this has been considered to conquer cancer!

If this technology is true, if it is really feasible and reliable after verification, then... Lu Li's scientific research achievement will be a great historical breakthrough!

We are witnessing history!

Professor Guo's heart set off a huge wave, and the hand holding the document was shaking slightly.

Taking a deep breath, Professor Guo adjusted his glasses and looked at the paper seriously.

Word by word, read carefully and carefully.

Modifying T cells to put cancer cells on the "hostile list" and weaken the ability of T cells to "call friends". This is the result of Lu Li's previous research.

Now, in this paper, Lu Li has given a new idea. On the basis of modifying the genes of T cells, Lu Li further modified the genes of B cells, so that B cells are shielded from "logistics and command capabilities".

In theory, Lu Li's idea is correct and feasible.

It's just... To achieve this goal, it involves very specific gene editing modification technology.

To accurately modify a certain function of a B cell, a very specific and precise gene editing operation is required, and it is very likely that... a genetic operation to modify a certain function of a B cell will not be possible for a long time.

"The idea is right."

After reading the paper, Professor Guo nodded and glanced at Professor He and Lu Li, "However, it's too early to talk about application, right? This is just a directional theoretical research paper, and it can't be put into practical application. segment."

Putting down the paper in his hand, Professor Guo glanced at Lu Li and Li and said, "To accurately edit the genes of B cells, it will take a long period of research to identify the gene targets and select the genes we want to edit. Fragment. Let's do this research first."

"no need!"

Professor He smiled and took out another document, "The experiment has been done. This is the experimental report."

"Uh?"

Professor Guo's eyes widened, "Has it been made?"

He quickly grabbed the experimental report from Professor He, and Professor Guo looked at it seriously again.

In this experimental report, Lu Li wrote out each step of the experiment in detail, and wrote various detailed data such as reaction time, ambient temperature, humidity, and equipment meter readings.

This...is it really successful?

Lu Li has completed all the experimental steps, and there is only one result to verify.

Professor Guo raised his head to look at Lu Li, the corners of his mouth were trembling, "You...have already completed all the techniques for genetic modification of B cells?"

"Yes!"

Lu Li nodded, "We came here this time to verify the results on your side."

"In more than two months, the B cell gene editing technology was developed. How did you find the gene fragment? How did you locate it?"

Professor Guo is still in disbelief.

I did the first experiment in the virtual lab!

For more than two months in reality, I did not know how many more experiments were performed in the virtual laboratory, and I did not know how much time it took to find the exact gene fragment.

Of course Lu Li couldn't say that, he could only say: "Maybe it's luck? It happened that I found the gene segment needed for B cell gene editing."

luck……

This reason was so powerful that Professor Guo was speechless.

Research is a process of trial and error. In this infinite trial and error process, luck comes first.

If you are unlucky, maybe you can't find the desired gene segment from three billion base pairs in a year or two, or even a dozen years.

If you're lucky... Maybe just like Lu Li, he found his target in just over two months.

Therefore, even scientists have to talk about luck.

"Go! We'll verify right away!"

Professor Guo didn't struggle with luck. He got up quickly, walked out of the office, and shouted at the busy graduate and doctoral students outside: "Stop what you are doing, go to the genetic laboratory immediately, and verify the scientific research results, hurry up!"

Is it the verification of scientific research results?

Is it the verification of Lu Li's scientific research results again?

They are all hard-working scientific research dogs. We can only follow the mentors to mix experience and start, but you continue to produce scientific research results.

It's really...it hurts my self-esteem!

The scientific research dogs, driven by Professor Guo, ran up and down one by one, but lowered their heads slightly when they passed by Lu Li.

Everyone came to the genetic laboratory. Professor Guo asked Lu Li to lead the experiment and instructed many scientific research dogs to do the experiment.

A group of graduate students and doctoral students started to help Lu Li, constantly extracting B cell samples, preparing transcriptases, and preparing splicing proteins.

Lu Li sat in front of the test bench, and various experimental materials were continuously collected into Lu Li's hands.

Turning on the electron microscope and turning on the gene gun, Lu Li kept editing B cells, making samples one by one, more than a hundred times in a row.

"Test passed! Genetically modified specimens have been obtained."

After Lu Li had done more than 100 genetic modifications, Professor Guo, who performed the tests later, had already found B-cell specimens that had been genetically modified accurately.

"Success! B cell gene editing technology, verified successfully!"

Professor He next to him couldn't help cheering.

"congratulations!"

"Lu Li, congratulations!"

There was a burst of applause in the laboratory, and everyone congratulated Lu Li for his successful technical verification.

This verification has proved that Lu Li's B cell gene editing technology is successful.

As for the exact preparation of the required genetically modified specimens after more than a hundred times, this is quite normal.

With the current gene editing technology, even if the gene segment to be edited is identified, it is impossible for the splicing protein and transcriptase to accurately cut the required position at one time, and it often cuts in the wrong place.

After 100 experiments, a specimen with correct gene editing can be obtained. This is the reason why Lu Li confirmed the experimental data. This result is already very good.

If you don't have this experimental data, you don't know how many years of experiments you have to do before you happen to hit the right spot!

"B cell gene editing technology has been verified!"

Professor Guo also announced the results with excitement, and then said: "The next thing to do is to verify the CAR-T anti-cancer technology."

"This verification will take some time."

Professor He took the conversation, turned his head and smiled at Lu Li: "However, your theoretical research paper can be published. The experimental data must be kept secret!"

"clear!"

Lu Li nodded, "The verification of the results of anti-cancer technology still needs to be arranged by Professor Guo."

"no problem."

Professor Guo agreed without hesitation.

...

That afternoon, China Medical Journal received another paper from Fudan University.

"The application of gene editing technology for T cells and B cells in CAR-T technology."

Seeing this title, the editor of "Chinese Medicine" was nervous, application? Is CAR-T technology mature?

Seeing the author of the paper again... Lu Li!

It's Lu Li again!

It's only been a few months? Has Lu Li researched CAR-T technology to the extent that it can be applied?

The editor is also half an insider, and naturally knows the significance of the maturity of CAR-T technology, which is equivalent to declaring to the world that cancer is no longer a terminal illness, and cancer can already be treated!

This Lu Li... is really amazing!

With a deep admiration in his heart, the editor of the magazine did not hesitate to forward Lu Li's paper to the reviewer.

...

"Currently, CAR-T technology is not yet mature."

In a large auditorium of Yenching University, oncology expert, professor of Union Medical College, and professor Wang Zhijian are giving an open class.

"Fudan's youth study Lu Li has made a major breakthrough in this technology. However, it still fails to solve the problem of immune factor storm."

"Science and technology are changing with each passing day. I believe that over time, maybe five years, maybe ten years, we will be able to overcome cancer, a chronic disease that exists with human genes."

"Of course, this requires the students here to study hard and study hard!"

As he was talking, Professor Wang Zhijian suddenly saw that his assistant held up his mobile phone and waved at him. His expression seemed a little excited and a little anxious.

Um? what happened?

Professor Wang Zhijian frowned. This assistant is his student. It stands to reason that it is impossible for an assistant to disturb him during class.

Since the assistant did this, there must be something very important.

"What's up?"

Professor Wang Zhijian stopped and turned to look at his assistant, his face a little unhappy.

"Professor, China Medical Journal, I have transferred a manuscript for your review."

The assistant raised the phone and answered quickly.

"Review? That's it?"

Professor Wang Zhijian's face was a little ugly, "Just this matter, you dare to interfere with my class?"

"Professor, this manuscript... is very important!"

The assistant said quickly, "This is Lu Li's paper. The latest paper on CAR-T technology."

Uh?

Professor Wang Zhijian was shocked, Lu Li? CAR-T latest technology?

"bring here!"

At the risk of interfering with the class, it is absolutely important to send in manuscripts for viewing. Professor Wang Zhijian hurriedly asked his assistant to bring the phone over.

Because the audio equipment was not turned off for this conversation, the students sitting in the auditorium also heard this conversation.

So...there was a lot of discussion in the classroom.

"Lu Li? Is that Lu Li from Fudan?"

"Lu Li has developed a new technology again?"

"Since I dare to disturb Professor Wang's class, it must be a very important paper."

"Could it be that Lu Li has made another breakthrough in CAR-T technology? Has he matured this technology?"

"It shouldn't be possible. Didn't you hear what Professor Wang said? Five years, or even ten years, will it be possible to develop mature CAR-T technology."

While the students in the audience were talking, Professor Wang Zhijian was a little stunned.

"The application of gene editing technology for T cells and B cells in CAR-T technology."

This is a theoretical paper, in which the gene editing technology of T cells and B cells is directionally expressed.

In fact, this kind of theoretical research paper can only be used as a reference, and has little practical application value.

However, the title of this paper dares to write the word application, and at the back of the paper, there are repeated experimental conclusions of Fudan University.

Which means...the technology has been proven. At least in terms of the genetic modification technology of B cells, Lu Li's paper is completely correct.

The afterlife is terrifying!

Professor Wang Zhijian suppressed the shock in his heart, put down his mobile phone, and walked back to the podium.

"Classmates, I received a paper just now."

Professor Wang Zhijian said to the students in the audience: "This is a paper published by Lu Li of Fudan University on CAR-T technology."

"In this paper, Lu Li proposed a new research direction and completed the preliminary verification."

Speaking of which, Professor Wang Zhijian paused and said, "Just now, I said that CAR-T technology will take five or even ten years to mature. Maybe... I was wrong!"

"Although the new generation of CAR-T technology developed by Lu Li still needs clinical trials to prove its efficacy. However, in theory, maybe... he has conquered cancer! From now on, cancer is no longer a terminal illness!"

"Fuck!"

"My God!"

At this moment, the audience was in an uproar.