I Just Want to Be a Quiet Top Student

The valid nomination period for the Nobel Prize is from September to January 31 of the following year.

Qualified recommenders are former Nobel Prize winners, Nobel Prize Committee or university professors specially designated by the Nobel Prize Committee.

Most of the prize winners who were still alive recommended Shen Qi to select the prize again.

The Nobel Committee also voted for Shen Qi, anyway Academician Stinga voted for it.

In the history of the Nobel Prize, some people have rejected the literature award, but no one has ever refused to accept the Nobel Prize in science.

As a two-time prize winner, Shen Qi prefers to leave the opportunity to others. His attitude is: "Let it take its course."

On the one hand, academician Stinga came to persuade Shen Qi to accept the award, and on the other hand, he did come to do academic exchanges.

"I am very sorry that I did not go to the LHC to participate in the great experiment of the black hole information paradox last year, but I read the full text of Professor Shen's paper on this experiment. The last LHC experiment proved that information will not disappear after entering the black hole But I have a doubt, after the information processed by the wave function enters the black hole, where does it go, and in what specific form does it exist?"

"Carl, do you really want to know?" Shen Qi smiled, with mystery in his calm.

"There is a Chinese proverb that says, if you hear the Tao in the morning, you will die in the evening. Yes, I want to know."

"You are good at Chinese, come with me."

Shen Qi then showed an unpublished document.

Academician Stinga was in a daze after reading it.

"Oh, it's a pity that this is just a deduction model... If it is real, it would be great..." Academician Stinga muttered to himself, he really felt that Shen Qi went to receive the Nobel Prize to show the Nobel Prize.

Afterwards, Shen Qi arranged for Sha Dongdong to take Academician Stinga to eat hot pot to calm the shock.

Next, Shen Qi received Academician Alexander Nelson.

Academician Nielsen is a medicinal chemist. He and his assistants are very interested in the LPJK1 project of Shen Qi Research Center.

The LPJK1 project is undergoing animal experiments, and the number of candidate active compounds is continuously decreasing. When there are only 5 active compounds left, major pharmaceutical companies including GLK have inquired about the relevant situation of Shenqi Research Center.

Not only pharmaceutical companies, some academic institutions are also paying attention to the latest trends of Shen Qi's laboratory. For example, a group of scholars such as Academician Nielsen of the Royal Swedish Academy of Sciences.

"Professor Shen, can we visit your medicinal chemistry experiment?" Academician Nelson asked.

"Of course." Shen Qi led his Swedish friend into the laboratory.

The Central Chemistry Laboratory is currently on a half-vacation. Most of the researchers have gone home for the New Year. Only Cao Fan, a doctoral student, sticks to his post to clean up.

The active compounds of the LPJK1 project were sent to the Tongzhou Animal Experiment Base for animal experiments. Twenty-two active compounds were continuously eliminated during the animal experiments, and there are currently 5 remaining.

In the laboratory, there is no tension and busyness in the past, and it is quiet and peaceful.

If Academician Nelson and his group proposed to visit the laboratory two months ago, Shen Qi would not have agreed.

Now, feel free to visit.

Academician Nielsen glanced left and right, and said: "Professor Shen, we saw the report on the 22 macrocyclic compounds synthesized by your laboratory in the patent report. We were very excited, so we flew to China immediately and wanted to Have an in-depth conversation with you."

When applying for a compound patent, it is usually necessary to attach a rough synthetic route, but patent applicants often do not give a complete synthetic route when applying for a patent.

Twenty-two compounds in the LPJK1 project of Shen Qi Research Center have applied for patents. Like most patent inventors, they have not given a complete synthesis route.

The LPJK1 project has innovated some important chemical methods in the process of preparing active compounds.

The eliminated 17 compounds caused certain side effects to animals, but these 17 compounds and the remaining 5 compounds are stable in terms of chemical structure and chemical properties.

Twenty-two compounds are all eight-membered heterocyclic compounds, which are macrocyclic compounds

In general, macrocyclic compounds are unstable, and they can exist during chemical reactions, but it is difficult to obtain stable final products. Because of the instability of macrocycles, organic reactions on macrocycles are rarely developed.

This is also the main purpose of Academician Nielsen's visit: "We all know that five-membered rings and six-membered rings are the most stable, and most chemically synthesized drugs also have structures of five-membered and six-membered rings. For the HIV drug darunavir, medicinal chemists will naturally think of the Paterno-Buchi reaction, or the Aldol reaction that plays a key role in another synthetic pathway."

"Hmm." Shen Qi nodded, expressing his deep agreement.

Academician Nielsen continued: "During the development of the prostate drug Xaltan, Pfizer designed many synthetic routes, and the core reactions supporting each synthetic route are different. In the end, Pfizer chose the synthesis with the Wittig reaction as the core. route, because the raw material price of this route is the cheapest. The drug synthesis of five-membered ring and six-membered ring has formed a very complete set of chemical synthesis system, and has developed a variety of name reactions. The synthetic route of eight-membered ring drugs , The core reactions involved are almost impossible to find.”

Shen Qi: "Yes, that's right."

Compared with Shen Qi's calmness, Academician Nelson became more and more excited as he talked: "Your chemical drug research and development team seems to have given a new idea. You have obtained 22 kinds of stable drugs with the newly developed rearrangement reaction as the core. active compounds of eight-membered heterocyclic rings! I would like to know whether there is a general rule for the synthesis of stable eight-membered ring compounds and even larger ring compounds based on novel rearrangement reactions? Or, can you share twenty The complete synthetic route of the two macrocyclic compounds, and the entire theoretical system supporting this synthetic route?"

"Professor Shen, isn't your synthesis route in the patent report too simple? Now that you have applied for a patent, can you give us a sneak peek and see more complete research results? In academic journals, publish the latest research results of macrocyclic compounds as soon as possible? Oh, Professor Shen, in my opinion, your research results can be compared with 'discovery and development of diene synthesis' and 'development of organic synthesis olefin metathesis' on a par."

Academician Nelson spoke eloquently, Shen Qi smiled noncommittally.

Bystander Cao Fan's heart was turbulent, what the hell? Discovered and developed the diene synthesis method, and developed the olefin metathesis method in organic synthesis... These research results are all at the level of the Nobel Prize in Chemistry!

But thinking about it, it's not surprising. Director Shen made a Nobel Prize-level achievement, which is also a routine operation.

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