I Just Want to Be a Quiet Top Student

"He Lin, you use a chemical equation as a metaphor for life. If you want to get the target product on the right side of the equal sign, you must sacrifice the original reactant on the left side of the equal sign. From a macro perspective, this metaphor holds water."

"But at the microscopic level, we all know that the number of atoms on the left and right of the equal sign remains the same, the total mass remains the same before and after the reaction, and the same atoms combine to form new molecules under certain conditions. Equivalent exchange is a permanent chemical reaction. Principle, if the ideal result cannot be obtained, it means that the equivalent process is not enough effort." Shen Qi drew a circle on a certain part of He Lin's group's experiment log.

"Just say that I didn't do well." He Lin accepted the leader's criticism calmly.

Shen Qi nodded and said, "It's expected."

He Lin laughed dumbfounded: "It's really straightforward."

Shen Qi turned to the blank page of the experiment log, and wrote and drew on it: "How can a new type of chemical drug be done in one go? There will definitely be various problems during the experiment. Regarding the next experiment of your group's project, My opinion is that optimizing from high-throughput lead compounds to obtain intermediates of isoindolinones will probably increase the cost by about 20%, and by my calculations, the chemical and optical purity will also increase. An increase of about 20% is acceptable. The increased cost is within your project budget, so there is no need to add money.”

He Lin stared intently at the abstract and specific retrosynthesis route written by Shen Qi. The target compound was a polycyclic structure, one of which was a larger seven-membered ring. There is only one functional group, which is vinyl, at C5.

"This is..." He Lin's body couldn't help shaking slightly. From a professional point of view, Director Shen has a very broad mind.

"This is my idea." Shen Qi continued to explain his thinking, "Although compound 7 is a very weak FXa inhibitor, replacing its thiophene fragment with 5-chlorothiophene can theoretically increase the inhibitory activity by 200 times Then we not only solved the problem of chemical and optical purity, but also greatly improved the inhibitory activity. I think this should be the LPJK1 receptor blocker we are eager to get."

He Lin fell into deep thought. Director Shen's idea was to split the C2/C3 and C3/C4 bonds to obtain an eight-membered ring compound on the basis of the seven-membered ring.

There is a rule clearly written in any organic synthesis textbook in the world. In the design of synthetic routes, try to avoid the production of macrocyclic compounds with more than eight members (inclusive). Because the chemical reactions in this area are rarely developed, the synthesis of macrocyclic compounds is also difficult and unstable.

Shen Qi ignored this iron law, and suggested that He Lin should explore eight-membered ring compounds in the next experiment.

Of course, He Lin has studied macrocyclic compounds, but the research is also very shallow. If it is not a scholar who focuses on theoretical development, few people will spend a lot of energy on such a thankless topic such as macrocyclic compounds.

Of course, He Lin also had doubts. She asked: "Director Shen's idea is subversive to a certain extent. I guess Director Shen must have come prepared. The things you wrote on paper are relatively abstract and fragmented, based on macrocyclic compounds. Does Director Shen have a systematic guidance document for theoretical research? I really want to learn."

"It's all here." Shen Qi pointed to his temple and said, "I have been studying macrocyclic compounds for a while, and this LPJK1 project can just verify my idea. It must be noted that my idea is not It must be correct, and I haven't fully constructed a self-contained theoretical system of macrocyclic compounds, and there are only semi-finished products at present. I will send you an email later, and you can find out the attachment in the email."

"Waiting for your email." He Lin originally wanted to perfect the experimental design of their group this morning, but Shen Qi's arrival opened a new door for her. masterpiece.

"There is a scientific view that people boil down to data, life is also an algorithm, and the essence of medicine is mathematics. He Lin, is your mathematics okay?" Shen Qi asked.

He Lin asked back: "People who are bad at mathematics, can't understand your chemistry articles?"

"That's not true, it's just that people who have passed the math test will have an easier time understanding what I wrote."

"When I was studying in England, I saw the proof of the Riemann conjecture you wrote."

"Do you understand?"

"In order to be able to understand, I specially studied analytic number theory. But I really don't understand your recent mathematical works, about the partial model of the unified mathematics, because there are too many mathematical knowledge to learn, covering almost all branch of mathematics."

"Have you studied analytic number theory? Then your math has passed, wait for my email, bye."

Shen Qi took off his white coat and walked towards the door of the laboratory.

Looking at Shen Qi's back, He Lin suddenly said, "Director Shen, I have a question to confirm."

Shen Qi turned around and said, "Say."

He Lin blinked curiously like a little girl: "Is the project code name LPJK really the abbreviation of 'Wife Health'?"

Shen Qi asked back: "He Lin, you have been in our center for more than a year, so what do you think LPJK stands for?"

He Lin answered as a matter of course: "L is Logic; P is Period; J is Joule, which can be understood as the energy in chemical reactions; K is Kinetics. I think the meaning of LPJK is based on the logic of organic synthesis strategies and elements. cycle, and fully utilize kinetic analysis and energy conservation law to obtain a new type of chemical drug.”

"You are a qualified woman in science and engineering, and the appraisal is complete." Shen Qi laughed loudly, and said again: "But you made a mistake in your brain, LPJK is not an abbreviation of English words, but an abbreviation of Chinese Pinyin. It really means my wife's health. mean."

He Lin was a little moved: "So the rumor is true, your wife is not in good health?"

Shen Qi's expression suddenly darkened: "My wife's health is not good, and she has risen to the height of the legend? It's no secret, she works in our Yanda University, and her health is indeed relatively weak. Friends around me know it. "

"You recruited so many returnees with Ph. D., established the LPJK1 project team, and even broke through the conventional challenge of macrocyclic compounds... So, Director Shen, your ultimate goal is to cure your wife's illness?" He Lin's mood fluctuated obviously. .

Shen Qi put away his gloomy look, and regained his confidence and firmness: "There are thousands of patients in the world, and my wife is just one of them. Healing a disease and saving a patient is not just a person, but a type of disease." patients. If the new drug developed by our laboratory can cure the type of patients including my wife, I will be very grateful for the efforts of all the researchers in our center."