I Just Want to Be a Quiet Top Student

The molecular skeleton of oxygen-containing heterocyclic compounds widely exists in many natural products with important biological activities and synthetic drug molecules.

In order to obtain high yields of target molecules, Shen Qi and the others designed a new synthetic route, but the yield of C01C-2 was still very low.

"You two have worked hard." Sitting in front of the computer, Shen Qi seemed to have a new idea.

"Our level is limited, and Director Shen is disappointed." Lao Yan said apologetically, he and Cheng Haonan are both masters in chemistry, probably because their education is too low, and the tasks assigned by Director Shen were not well completed.

"Lao Yan, do me a favor, go to the Mathematics Institute and give this to Ouye." Shen Qi handed Lao Yan a file bag, which contained mathematics materials.

"Okay." Lao Yan took the file bag with a sense of crisis in his heart. If the scientific research task is not completed well, he will be downgraded to a handyman.

Shen Qi took out some coupons and gave them to Cheng Haonan: "Old Cheng, there is a newly opened restaurant across the street after leaving the east gate of the school. The dishes are pretty good. This is a voucher. Go and pack some dishes and come back with us. Three will have a meal at noon."

"OK." Cheng Haonan also felt a sense of crisis, he was reduced to a takeaway.

Lao Yan and Cheng Haonan left the center with heavy steps, and followed Shen Qi's instructions to do their own things.

Compared with developing a new organic reaction, sending a piece of information to Mrs. Shen and buying a takeaway, this kind of business is not difficult. The two quickly completed the task and returned to the center.

The whiteboard is filled with chemical molecular formulas and reaction steps, apparently written by Shen Qigang.

"This is……"

"Is this..."

Lao Yan and Cheng Haonan were shocked. In just half an hour, Director Shen came up with a new plan?

"Come, come, eat, chat while eating." Shen Qi pointed to the takeaway box that Cheng Haonan was carrying.

The three ate fish and gnawed meat, discussing the optimization plan of C01C-2.

It was mainly Shen Qi who was talking, and the other two listened attentively.

"Based on your work results, I conducted an analysis. Using o-methoxybenzyl alcohol instead of o-carboxybenzyl alcohol and o-carboxybenzyl styrene is difficult to proceed even under optimal conditions. Using methyl-protected benzene Ethylene instead of o-carboxystyrene and o-carboxybenzyl alcohol will not work either."

"So I speculate that the possible activation mode of this reaction is that the chiral phosphoric acid simultaneously forms hydrogen bonds with the in-situ-generated intermediate of o-carboxybenzyl alcohol and o-carboxystyrene, which promotes the occurrence of this 4+2 cycloaddition reaction, thereby improving The total yield of C01C-2. From the perspective of the reaction mechanism, it is reasonable to deduce that the electronic effect of the substituent has a certain impact on the enantioselectivity of the reaction. Of course, this is all my speculation, and everything is subject to experimental data. " Shen Qi used his lunch time to explain his idea.

After lunch, Lao Yan and Cheng Haonan came to the chemistry laboratory to verify Shen Qi's conjecture.

The two had mixed feelings. If Shen Qi's speculation was correct, then a new and valuable organic reaction would be born in Yanda's laboratory. This is exciting news.

At the same time, it also shows that the academic level of Lao Yan and Cheng Haonan is far behind Shen Qi.

The two of them worked hard for several months but couldn't get a satisfactory result, but Shen Qi got it done with just one meal.

The academic problems can only be solved by Shen Qi. Lao Yan and Cheng Haonan pessimistically think that the necessity of their own existence is not high.

"Old Yan, tell me, Director Shen is really so amazing?"

"I have to admit that Director Shen's theoretical skills are extremely profound and unfathomable. Once he shows off, it will be so beautiful that people can't understand it, but he looks very powerful."

"Your sister, you made a mistake!"

Cheng Haonan roared and quickly stopped the experiment.

The two were busy talking, and Lao Yan mistakenly added dichloroethane as a catalyst to the reaction vessel, and the mistake in adding the medicine caused the laboratory to be filled with smoke.

"Missed, damn it!" Lao Yan dealt with the experimental mistakes in a low-key manner, and did not report to the center leadership. He increased the ventilation and restored the laboratory to a normal state.

The two of them no longer dared to gossip about Director Shen, and just concentrated on doing experiments.

This experiment lasted for two days and two nights, when a new day came and the sun rose.

The target product was successfully synthesized, it is C01C-2, it was synthesized nearly a hundred times by Lao Yan and Cheng Haonan within a few months, but none of them passed the test.

Will it happen again this time?

After finishing the H NMR, C NMR, IR and other tests, Lao Yan showed a demented expression: "The total yield is 55%..."

Cheng Haonan murmured: "The ee value is 70%... Shen Qi is also a god."

The experimental data is perfect. This data means that the new reaction conceived by Shen Qi is reasonable. The addition of this reaction will cause the total yield of C01C-2 to skyrocket from less than 1% to 55%.

C01C-2 is an enhanced version of C01C, which theoretically has safer drug properties.

Of course, how safe C01C-2 is needs to be confirmed through animal experiments and clinical trials.

As chemists, for Lao Yan and Cheng Haonan, the improvement of an experimental procedure to obtain the target compound with a yield of more than 50 times is a divine operation.

And this divine operation, they can't realize it.

"Director Shen's operation is really incomprehensible, but I have to admire it." Lao Yan saved the experimental data, no matter what, the two of them participated in the experimental process for this new reaction.

Cheng Haonan comforted Lao Yan: "Brother, our positioning needs to be adjusted. In fact, you are a skilled operator like me, and the most advanced route design and reaction mechanism research are things that chemists do, and Director Shen does. Things. What we have to do is to implement Director Shen's synthesis strategy and complete specific synthesis experiments. To put it bluntly, we are just two experimental dogs with strong hands-on ability. If you think about it, you may not be so sad."

"Your remarks are too real, which has caused me strong discomfort." Lao Yan thought about it thoroughly. Why did he have a sense of crisis before, why did he feel sad because of the unattractive data, and even doubted his academic level?

Because Lao Yan has been with Shen Qi for a long time, he takes Shen Qi as an example, and he wants to do what Shen Qi can do.

However, the facts proved that what Shen Qi could easily do, Lao Yan and Cheng Haonan couldn't do it even if they tried their best.

"Everyone's brain structure is different, let's go and report the results to the leader." Cheng Haonan and Lao Yan came to the director's office with the experimental data, and happily reported the results.

The two have defined their own positions. For a long period of time, neither of them can become strategic route designers and chemists full of whimsical ideas.

Do what you do and love what you do, no matter what position you are in, just do your job well, and that will be fine. Everyone can reap happiness and create life value in line with their own positioning in the ordinary.