Hello, 1983

Liu Qingshan really has this idea when it comes to digging the wall. As Jiapigou and Liu Qingshan's own industries become more and more large, the talent gap will also increase.

However, Professor Zhong did not mean to accuse Liu Qingshan. If their students chose to stay, he and Professor Zhang would not stop them.

They even have the same intention of joining Jiapigou Pharmaceutical Factory, especially Professor Zhong, who has now retired and was rehired to continue to use his residual energy.

After the dividend meeting was over and the guests were sent off, Liu Qingshan had time to go to the eldest brother-in-law.

When I entered the room, I saw three writers sitting there drinking tea and chatting, and they seemed to be talking very speculatively.

Among the three, Lu Writer is the head, Gao Wenxue is the second, and Yu Writer is the most junior.

Writer Yu was also envious after hearing that the two works had been published abroad and that they had received a lot of money for their writing.

When Liu Qingshan came in, three people were talking about this topic.

Liu Qingshan smiled and said, "Brother Yu, if you have the opportunity in the future, you can also translate your works."

Later, he was alive and was awarded the French Knights Medal, of course he had this qualification.

Yu Hua waved his hand slightly embarrassedly: "I'm still a little far from Big Brother Wang and Big Brother Gao."

Liu Qingshan also sat down next to him: "Brother Yu, you have just entered the golden period of creation, and you are short of a masterpiece. Do you have any ideas recently?"

"I have an idea. I discussed it with Brother Wang and the others just now."

Writer Yu did not hide it, and just said one of his own ideas.

He wanted to write about a person who lived tenaciously through the big times, and all the relatives in his life left him, and in the end there was only an old cow to accompany him.

Liu Qingshan's eyes lit up: Isn't this the one that lives?

It is about being alive, but saying goodbye to death again and again. It is about the endurance of human beings in the face of hardships and the meaning of life.

So Liu Qingshan couldn't help but ask: "Several writers, I want to hear your opinions, why do people live?"

This question is about to rise to philosophical heights, so all three writers fell into contemplation.

Writer Lu lit a cigarette,

Breathing quietly, he said in a slow tone:

"If you think about it, everyone's life is also a world. Even the most ordinary person has to fight for the existence of his world. In this sense, in these ordinary worlds, no one is ordinary. of."

"When I live, I have to work like an ox and dedicate like the land."

In the curling smoke, Writer Lu explained his understanding of life, and the other three people in the room couldn't help but feel awe.

Even the most ordinary person has to fight for the existence of his world. This is the meaning of life.

Gao Wenxue also rolled a cigarette: "I think people should live for their beliefs. Your beliefs can make your family and yourself live better, or you can make society and the country better. it is good."

"If you have faith, you will not live in vain."

The other three nodded in the same way.

Finally, everyone's eyes turned to Writer Yu, but he shook his head shyly:

"I haven't thought about it yet. Maybe when I figure it out, I can start writing this book."

Writer Lu and Writer Gao were not disappointed, because they were both experienced people and knew the importance of this to their creation. It is a soul-like existence.

"Qingshan, what do you think?" Writer Lu suddenly threw the question back.

he?

Writer Yu was a little surprised. In his opinion, this is something that writers should think about, and as far as he knows, Liu Qingshan is just a businessman.

Businessmen value profits. Although Liu Qingshan does not have that copper odor, Writer Yu does not think that the other party has this qualification.

Perhaps seeing Writer Yu's expression, Writer Lu smiled slightly:

"Actually, even if we add up the manuscript fees, we can't keep up with the fraction of Qingshan's manuscript fees."

Writer Yu couldn't help blinking hard: "Mr. Liu, are you also a writer?"

If it were an ordinary person, I'm afraid I wouldn't ask so directly, but most writers have their own personalities.

Of course Liu Qingshan doesn't care: "I mainly collaborate with others, and most of them are published abroad."

This time, Writer Yu was even more shocked: "I also came into contact with a lot of foreign writers' works in the College of Literature, such as Walden Pond, Hundred Years of Solitude, etc. By the way, there is also a recent book Shepherd Boy's Fantasy Journey that is also worth reading. "

The corners of Liu Qingshan's mouth twitched slightly: "When I published books abroad, I used the name Mountain."

With a swish, Writer Yu stood up at once. He stood a little confused, and when he touched the table, the tea in the tea bowl swayed out:

"You, you are Mountain?!"

There was a strange light in Yu Writer's eyes.

He finally understands now: of the four people present, he is indeed the weakest one.

A sense of powerlessness welled up in Yu Writer's heart, but it was quickly replaced by a strong unwillingness, and the unyielding energy in his bones was completely inspired.

Liu Qingshan took a rag, wiped the table, and said while wiping: "I think it is an instinct for people to live."

"Just like a small grass, a big tree, a butterfly, or a tiger, survival is an instinct."

With a snap, Writer Yu slammed his fist hard. He instantly found inspiration and shouted excitedly:

"Yes, man lives for the sake of being alive, not for anything other than being alive."

After tossing and turning, he repeated several times in his mouth, and then suddenly grabbed Liu Qingshan's hand:

"Thank you, thank you, for letting me capture the soul of this work at once!"

Gao Wenxue, who was next to him, looked at this familiar scene with a smile, because he had a personal feeling: Qingshan is such a person who can strike his soul.

After the excitement, Writer Yu sat down again, and the excitement and excitement on his face were still difficult to calm down:

"Maybe I am not eligible to receive the Jiapigou Literature Award yet, but please believe me, when my new work comes out, I will definitely be eligible."

Liu Qingshan also smiled and nodded, of course he believed it.

The next day is Xiao Nian’er, and of course eating dumplings in the morning.

Liu Qingshan rushed to the pharmaceutical factory early after eating because the trial production was going to be carried out today.

Everyone also paid attention to this research, and as a result, they went to a large group of people.

When we arrived at Jiapigou Pharmaceutical Factory, we were also eating dumplings there.

The main reason is that there are many people who eat dumplings and few people who make dumplings. This is still the case with Professor Zhong and the others.

Those foreigners are also very fond of dumplings, the kind that can eat a curtain.

"Liu, have you eaten?"

Foreigners also follow the local customs and greet Liu Qingshan in such a language that is very rich in Chinese characteristics.

"Liu, try one. It's very refreshing."

Mason's ears were wrapped in white gauze, and he skillfully picked up a sauerkraut-stuffed dumpling with chopsticks.

After everyone finished eating and changed into work clothes, they went to the workshop.

The raw materials have been delivered, twenty kilograms of dried yew seeds, quietly packed in a large glass jar.

At this critical moment, everyone's hearts can't help but get nervous, and Kevin said in his mouth:

"Paclitaxel is the most abundant in the bark of Taxus chinensis. With Taxus chinensis, about 13.6 kg of bark can be extracted to 1 gram of Taxol."

"I don't know how much paclitaxel is in the yew seeds here?"

This is also the question that everyone is most concerned about, and no one has the bottom line.

The reason why the drug paclitaxel is precious is that the yield is too low, and the bark of the yew is relatively thin. How much bark can a tree produce?

Treating a patient requires the bark of several yew trees, which are already scarce and slow-growing.

Cutting down trees and peeling the bark to extract yew will be criticized by environmentalists.

The superposition of various reasons has resulted in the preciousness of paclitaxel.

"Go ahead and hopefully we can do a miracle."

Liu Qingshan waved his hand, he is very confident in the local yew, because this has been proved later.

These technicians began to perform their respective duties, and as the equipment was turned on, there was a low buzzing sound in the workshop.

The laymen who came to visit also looked solemn, because they also knew the significance of this experiment.

Refining paclitaxel is a very complicated process, because the structure of paclitaxel belongs to a tricyclic diterpene compound, and the structure is extremely complex.

There are also scientists who want to synthesize artificially, and they have indeed succeeded in living a few years later.

It's just that the reagents and materials required are expensive, and it is impossible to achieve large-scale mass production.

Later, a semi-synthetic method was developed, using a cedar tree similar to Taxus to synthesize paclitaxel. The process was also more complicated, so the price of paclitaxel did not drop much.

The waiting process got a little boring, so the fourth youngest suggested to lead those singers to a big show in the countryside.

This idea was immediately welcomed, so everyone covered them tightly and excitedly followed the fourth and fifth.

"Little stool, don't go, I have something to do with you." Liu Qingshan shouted.

The little stool likes to join in the fun the most, and immediately started pouting, and then heard Liu Qingshan continue to say: "I found a suitable song for you."

Wow, the small stool screamed strangely and rushed towards Liu Qingshan.

Who does not know about the company under the big tree, the songs created by President Liu are basically classics, who doesn't want them?

The others also stopped and looked at the small stool enviously.

The little fourth is a little dissatisfied: "Brother, are you robbing me?"

Liu Qingshan waved his hand: "Everyone go for a walk first, I just find a small stool to try first, if possible, everyone can participate."

Everyone couldn't help but rejoice: Is this the rhythm of holding a concert of 100 singers?

So they all followed the little brother and ran happily without a shadow.

However, there were some who didn't go. A Mao didn't like to join in the fun, so he stayed.

It happened that Liu Qingshan also needed her, so he led the two girls, one big and one small, into the activity room of the pharmaceutical factory.

It was not until the market was over at noon that the fourth youngest returned with a full load of the army.

These singers were holding candied haws and large candies in their hands, and they were all elated.

And even more exciting news came from the workshop: Paclitaxel has been refined!

When everyone heard it, they all rushed into the workshop. When Liu Qingshan rushed in, they saw the technician named Carl holding a small test tube with a small half of white crystals in it.

After the weighing, Carl's face also flushed: "Oh, it's 30.5 grams in total!"

"We used 20 kilograms of yew seeds to extract 30.5 grams of paclitaxel, and the content reached 0.15%, which is unbelievable!"

Laymen don't understand, but they and these experts know that even in the bark of Taxus brevis, which is recognized as the highest content, the content of paclitaxel is only 0.069%.

And don't underestimate these 30 grams of paclitaxel, which is worth nearly $10,000 at the current market price.

"Could I have made a mistake somewhere?"

Kevin did not follow the excitement, but suspected that there was a problem in which link, and it was not paclitaxel that was extracted.

"It has been tested, and it is indeed a crystal of paclitaxel." Carl was very dissatisfied with Kevin's suspicion.

Although he was also shocked, he was shocked that the content of paclitaxel in the yew seeds here was so high.

But you can't question his professionalism.

"Success, we succeeded!" In the workshop, cheers rang out.

The members of this makeshift team hug each other and smiles bloom on everyone's face.

Kevin was also elated: a total of tens of thousands of kilograms of yew seeds, according to this ratio, can extract tens of kilograms of paclitaxel, which is also worth millions of dollars!

"I'm coming!"

Lu Xiaolong just used a jeep to pick up the bearded Principal, and this guy was still screaming: "It's better to come by chance, just made it, it's still hot, give us Principal Xu to eat while it's hot!"

Do you think it's a bun that just came out of the drawer? Paclitaxel is very toxic, and the dosage must be carefully calculated.

Moreover, this substance is insoluble in water, and it is more troublesome when injected, and it is easy to cause allergic reactions. First, you have to inject dexamethasone and the like to adapt.

In fact, this year, the clinical trial of paclitaxel is only in the second stage, and it will not be gradually improved until the 1990s.

When Principal Xu saw this battle, he was also a little puzzled, just like Liu Qingshan asked:

"I'm afraid this thing is quite expensive. I'd better not use it. I feel pretty good now."

Just as Liu Qingshan was about to lie and say it was the price of cabbage, the little Liuzi next to him said quickly:

"Uncle Xu, of course it's expensive. Just a little bit is worth ten thousand dollars."

Hearing the bearded principal waved his hands again and again: "No, no, it's not worth the price if you sold me."

It made Liu Qingshan a bit of a headache. He knew Principal Xu's temper, and he had the stubbornness of a scholar in his bones.

So Liu Qingshan could only say: "Principal, this thing is useless, you have to cooperate with clinical trials."

Principal Xu was also delighted: "Co-authoring takes me as a guinea pig, right? It's even more useless."

Of course he understood Liu Qingshan's kindness in his heart, but he really couldn't use such a precious thing.

There was no way, Liu Qingshan could only wave to A Mao, it was time for her to persuade the bearded principal.

Of course, A Mao played to his strengths and began to sing the songs that Liu Qingshan had just taught her.