Doctor Chen, Don't Be a Coward!

Chen Nan's words were really domineering.

Directly fooled everyone on the scene!

"They... are not worthy?!"

soon!

The audience fell into a discussion.

Yuan Chaomin and the others looked confused. They looked at Chen Nan, apparently unable to understand the confidence behind Chen Nan's words.

Damn it!

They really panicked in their hearts.

They came to attend the meeting, and indeed they learned a lot of professional knowledge and the concept of new drugs.

Yuan Chaomin, Lu Shouyue and others naturally hoped that Chen Nan's drug would get attention and publicity on this platform.

After all, this is the scene of the world's top tumor new drug launch.

But!

Chen Nan actually started to fire at NMPA directly here, saying that their next-generation sequencing has fallen behind, and they are not worthy of genetic testing at all.

These words made everyone a little annoyed in an instant.

As expected, soon!

More people began to question Chen Nan.

After all, besides experts in the field of tumors, there were also many pharmaceutical companies presenting new drug launches.

What they got was also the sequencing results from NMPA.

A targeted drug must be sequenced to prove that it has a targeted effect on cancer cells, and only then can it obtain the threshold standard for targeted drugs.

Otherwise, even the name "targeted drug" cannot be pressed.

And after Chen Nan was denied by the NMPA sequencing company, he turned his firepower directly on the opponent.

They even said that the other party was not worthy of sequencing.

How arrogant and domineering is this?

In an instant, more and more people in the audience began to criticize Chen Nan.

"This... Chen Nan is too arrogant!"

"Yes, the NMPA sequencing company is the current international standard, what qualifications does he have to say that he is not worthy!"

"That's right! What qualifications does he have to deny NMPA's sequencing standards?"

"Huaxia hasn't even developed a targeted drug, and it's ridiculous to talk about qualifications!"

"Yeah, I thought this young man was good, but this tone is too loud!"

...

All of a sudden, more and more people began to question and even criticize Chen Nan's words.

On such a stage, it is necessary to speak with strength and discuss facts with evidence.

It's not who has a loud voice, who has a hard tone, and who is more likely to quarrel.

Seeing Chen Nan like this.

Geoffrey, who was originally disgusted and angry with Chen Nan, suddenly laughed.

He was a little worried about Chen Nan's new medicine.

However, NMPA directly denied the targeting effect of icariin.

Even here, Chen Nan directly started to retaliate against the other party.

There was such a buzz right away that Joffrey didn't even have to stand up for himself.

it's good now!

Chen Nan can be said to be enemies on all sides.

No matter how many tongues he has, can he stop so many experts present?

Tilson felt dandruff and tingling.

Damn, isn't this Chen Nan too courageous?

Yesterday, it was Geoffrey who directly attacked Gilead. Today, Gilead's stock price continued to slump.

To know!

Some time ago, Gilead's stock price can be said to be a very rare and good thing.

Fortunately, many stockholders are beginning to hesitate.

The United States can be said to be a country where all people participate in stock trading, and many people's savings are in the stock market.

And Chen Nan's question about Gilead yesterday was quickly published in relevant medical newspapers, causing the other company's shares to slump instantly.

And today!

Chen Nan even directly targeted the NMPA Precision Medicine Company.

This operation made Tilson's waist tremble a little.

but!

Most people showed strong dislike for Chen Nan's words!

Even Drizzt frowned a little at this moment.

Although he doesn't like those profit-seeking pharmaceutical companies, it is undeniable that they have made contributions to the development of the pharmaceutical industry.

However, Chen Nan is directly angry at NMPA, which makes Drizzt a little unhappy.

Although the World Oncology New Drug Conference welcomes new pharmaceutical products from all over the world, as long as they pass the review and have recommendations from regions or countries, they are eligible to enter this conference.

However, that doesn't mean you can talk nonsense.

soon!

Someone stood up.

This is Brooks, vice president of the Cancer Society.

Brooks got up and looked at Chen Nan and said:

"Professor Chen, your speech yesterday was a speech with suggestions for the World Cancer Society."

"But that doesn't mean you can talk nonsense!"

"The significance of NMPA's existence has proved the value of the other party. Over the years, the strict review of targeted drugs has become known to the industry."

"Many countries' food and drug administrations will accept and recognize each other's standards by default."

"I want to know, why do you judge the other party so much?!"

"Is it just because you haven't been certified by the other company?"

"If so, you are not a qualified tumor researcher."

Brooks' words attracted the attention of many people, and everyone started talking in low voices.

Joffrey was overjoyed when he saw this scene.

It can be said that he doesn't have any good feelings for Chen Nan now.

I can't wait for the other party to encounter difficulties from everyone.

Chen Nan heard the sound and said with a smile: "Sir, I am not talking nonsense."

"NMPA is still using next-generation gene sequencing technology."

"And my drug, icariin, is a drug with multiple molecular targets."

"He failed the test, which is a very normal thing."

"Actually, starting from this point, it can just prove the shortcomings and loopholes of next-generation sequencing."

"Besides, it's within my expectation that I can't pass the other party's test!"

"Akolading's truly great place lies here!

It is different from the drug synthesis of screening targets, and it is not a one-way gene target.

However, the defect of next-generation sequencing is obvious. It is impossible to accurately predict gene fragments, which can easily cause errors!

If it is a targeted drug for the screening target, it can be verified through screening.

but!

Acradine is a multi-target small molecule therapeutic drug!

This means that the detection is very difficult and not specific, and it is easy to be negated by the second generation sequencing! "

Following Chen Nan's words, the audience fell silent instantly.

Because more and more people seem to realize that Chen Nan is not aimless.

Not to mention nonsense sophistry.

The other party really has something to say.

At present, the main targeted drugs for anticancer drugs are all screening target types.

The next-generation sequencing can detect it and it seems to be normal.

Chen Nan saw that everyone in the audience was obviously attracted by his remarks.

I was overjoyed.

he knows!

The opportunity has come.

Chen Nan slid the device in his hand directly, and a detailed flow chart appeared on the big screen!

"Everyone can take a look!"

"That's the specific extreme of the drug alcaridine."

"The core mechanism is down-regulation of inflammatory pathways!

That is, through the inhibition of IL-6/JAK2/STAT3 and TLR-MyD88-IKK-NFκB pathways, the expression of TNF-α, IL-6, and PD-L1 can be down-regulated to exert anti-tumor effects.

At the same time, through the regulation of MDSC\\Tregs cells of immunosuppressive cells, the regulation of immune microenvironment can be realized and tumor growth can be inhibited. "

"This is a pathway very close to the activity of human immune cells!"

"Human immune cells are also a multi-target operation mechanism!"

"The same is true for our Acradine, it doesn't just act on tumor cells in the form of a drug!"

"It is through the regulation of immune cells to achieve the regulation of the immune microenvironment, so as to keep the development of cancer cells!"

"If we really want to say which drug our drug is more similar to, it must be CAR-T cell therapy."

"but!"

"We are different from the other party in modifying T cells so that they do not meet the requirements of the human body."

"Instead, drugs are used to enhance the regulation of immune cells and make the body immune to cancer cells!"

The audience are all experts in the field of tumors in the world!

Those who can be invited to participate in the meeting are by no means ordinary people.

On the stage, Chen Nan didn't have any timidity in his eyes, he was full of vigor, as if scolding Fang Qiu.

Turn a blind eye to the hundreds of experts and scholars in the audience, as well as journalists and media from pharmaceutical companies and professional journals around the world!

Those eyes were full of confidence.

Soon, Chen Nan's words attracted the attention of many people.

They began to think carefully along Chen Nan's thinking.

At this time, everyone did not continue to blame each other.

Seeing this, Geoffrey panicked.

He faintly felt something was wrong.

The same goes for Brooks.

Accompanied by the approach of time every minute and every second.

Chen Nan's narration has attracted more and more people.

As for Chen Nanyue, the people below became more and more aware that something was wrong with this matter!

Because... Chen Nan began to gradually lead everyone to think in a new direction!

That's the problem with genetic sequencing!

That's right!

James Harken quickly realized this.

He even looked at Chen Nan in surprise, he faintly felt that something was wrong...

What is Chen Nan going to do?

Drizzt beside him was even more frowning!

He seemed to think of something.

suddenly!

He opened his eyes suddenly, and looked at Chen Nan on the stage sharply.

He finally knew what Chen Nan was going to say!

Sequencing!

Chen Nan is not just releasing new drugs today.

It is undeniable that this drug called "acoladine" is indeed very attractive.

It is also a novel way of thinking!

but……

This is obviously not the reason that shocked him the most.

Chen Nan didn't seem to care too much about this drug.

Instead, it is taking this drug as an example to guide everyone's thinking and carry out a conceptual transformation!

In normal times, Drizzt would definitely stop it.

but!

At this time, Drizzt did not!

Because he thought of a special possibility.

That is... Where is the result of Chen Nan's guidance?

He took a deep breath, a little excited.

Could it be... Is Chen Nan really in the next generation of sequencing technology?

That's right!

Acradine, under the next-generation sequencing, cannot be completely denied. On the contrary, this multi-target drug is easier to identify.

but!

Under the current environment of screening targets, it is impossible for NMPA to pass Chen Nan!

Because once passed, there will be many problems!

First, the emergence of multi-target drugs will expose the defects of NMPA!

Second, next-generation sequencing technology is a phased product!

as expected!

With the passage of time every minute and every second.

Everyone in the audience is a top mission in the field of tumors.

Whether it's the representatives of those pharmaceutical companies, or the experts from the cancer association present, or the leaders of academic journals.

They all vaguely grasped a little bit of something.

That's next-generation sequencing...it seems to be falling behind the current tumor environment.

Targeted drugs are making progress!

This is undeniable.

With the continuous innovation of tumor-targeted drugs, drug resistance is constantly increasing. If sequencing technology cannot keep up, this will lead to a big disadvantage.

That is curative effect!

Targeted drugs have always represented the pioneers of tumor drugs in the world.

But in fact, this is also a huge network of weaving.

When the sun rises, all deceptions will be self-defeating.

Oncology pharmaceutical companies have obviously reached an agreement with NMPA testing companies long ago.

That is the technical difficulty and mystery of maintaining targeted drugs.

But!

As the efficacy of the second-generation targeted drugs has become worse and worse, the third-generation targeted drugs have gradually entered the market, which has reached the peak and limit of the second-generation sequencing technology.

If you go further.

They simply can't meet the sequencing requirements anymore.

The error rate will be greatly increased.

The difficulty of the fourth-generation targeted drugs is also increasing.

to be honest.

Targeted drugs, sooner or later, will follow in the footsteps of antibiotics.

Accompanied by the enhanced drug resistance of cancer cells and changes in nucleic acid genes, this will lead to the dilemma of targeted drugs.

Precision medicine has already encountered a big problem...

so!

With Chen Nan's speech, more and more people realized...Chen Nan might talk about "Three Generation Sequencing"? !

Thinking of this name, almost everyone's body could not help but tremble.

If so!

This……

This is too exciting.

Once the third-generation sequencing technology emerges, oncology drugs are bound to usher in a new opportunity for development. Similarly, this will also allow oncology pharmaceutical companies to undergo a new reshuffle.

for a while!

More and more people couldn't help wrapping their clothes tightly.

Although the temperature on the south coast of the United States is not cold.

However, even so, everyone in the Rochester Hotel still felt a kind of excitement before the climax!

This is even more true for Yuan Chaomin and others.

Before, they were full of curiosity about Chen Nan.

Even... Everyone didn't understand what Chen Nan was going to do.

but!

With Chen Nan's analysis of the drug Acradine, and with Chen Nan bringing out some special information from the third-generation sequencing, it seems... a mysterious picture scroll is unfolding!

Lu Shouyue and others looked at Chen Nan on the stage, and suddenly felt a little strange.

Is this Xiao Chen?

Is this really Xiao Chen who came here with them from China for a new drug launch, the first time to participate in such a high-end international conference?

This……

Looking at the audience, how many people looked at Chen Nan with burning eyes.

That's right!

Tilson was all excited.

He is waiting!

Wait for Chen Nan to say the four words "Three Generation Sequencing".

James Harken is waiting!

Dane is waiting too!

And Drizzt is also waiting.

In the room, hundreds of people almost stood up, waiting for Chen Nan to say the words "three generations of sequencing"!

pity!

Just at this time.

Chen Nan looked up at the time, and suddenly bowed to everyone!

smiled and said:

"thanks!"

"This concludes my report for today."

"Akladine will definitely become a targeted drug with trans-epochal significance!"

"because……"

"Secret!"

After finishing speaking, Chen Nan walked straight to the audience.

And this scene!

Immediately, everyone in the audience was dumbfounded.

This?

this one?

This is the end?

Does it fit?

That's right!

Everyone was dumbfounded.

We're all posed, and our interest is maxed out...

you go down?

I'm all undressed, you show me this?

That's what it feels like!

Chen Nan came back suddenly and added:

"Today is the press conference for new tumor drugs."

"We only talk about new drugs, nothing else!"

"thanks for your support!"

After finishing speaking, Chen Nan walked down the stage.

And hundreds of pairs of eyes were staring at him.

Although Chen Nan didn't say a single word of "Three Generation Sequencing".

but!

No one doubts whether Chen Nan understands the technology of third-generation sequencing!

even!

Many people started to think about it.

Could it be...

Three generations of sequencing, already out?

for a while!

Everyone's souls were hooked away by Chen Nan unconsciously.

As a result, the next new drug launch conference seemed a little less exciting.

Jewels come first.

Everyone feels that after drinking a good wine, the taste is taken away, and then... the taste after that is always worse.

Those pharmaceutical companies are also dumbfounded.

Damn it!

Originally, I wanted to rely on this new drug to show it on such a stage.

But……

No one was even interested in asking questions.

We have been preparing for a long time, okay?

Can you ask me a question?

Even one question is fine!

pity!

Everyone's thoughts are on Chen Nan.

Like a scumbag, he took away the thoughts of all the beautiful girls, and then patted his ass and left?

Really are……

Scumbag!

Pooh!

...

...

The meeting is over soon.

This will mean that this time the new drug launch conference has come to a successful conclusion.

Drizzt came to the stage and made a summary.

There is a grand luncheon at noon.

This luncheon is of a business nature.

The experts who came to the meeting will have friendly talks with pharmaceutical companies here, and get the qualifications for donating medicines and participating in clinical trials of medicines, as well as opportunities for free diagnosis and treatment.

In the past, Yuan Chaomin and others were generally lonely and lonely.

Compared with those lively other experts, they only obtained some qualifications symbolically.

but……

This time!

But it is completely different from before.

The Huaxia expert group actually obtained an independent banquet restaurant.

The restaurant is as luxurious as a meeting place.

Before the luncheon started, a group of people could not wait to walk in.

He and Chen Nan and others left their contact information one after another.

"Professor Chen, it's a pleasure to meet you. I'm the vice president of Pfizer Pharmaceuticals. I think we will have many cooperation projects!"

"We are very interested in your icariin."

"I think we can have a deeper understanding and communication."

...

"Professor Chen, hello, I'm from Johnson \u0026 Johnson..."

"Professor Chen, it's a pleasure to meet you. We are Roche...I think that you are qualified to donate medicine to our senior professor, and we will give you a special right to donate medicine..."

"..."

...

More and more big-name companies have come to seek further cooperation with Chen Nan.

These pharmaceutical companies are not stupid!

There is only one purpose for their humility.

That is three-generation sequencing.

Almost everyone has a premonition that Chen Nan definitely has information about the third-generation sequencing.

Otherwise, it would be impossible to make such a demonstration at the scene of new drug release.

Chen Nan immediately obtained the authorization of advanced drug donation qualifications from almost all pharmaceutical companies.

In the United States, there are many clinical trials, and these trials are generally phase III clinical trials with a high safety factor.

And, the key is free medical care.

You must know that the price of these new drugs is very expensive, and the price is tens of thousands or hundreds of thousands. For many families, it is very difficult.

However, the quota for Phase III clinical trials is not easy to get.

Phase III clinical trials of common drugs still need to take the initiative to spend money to find people!

However, for those targeted drugs with high maturity and expensive drugs, the opportunity for a clinical trial is very rare!

But Chen Nan held a lot in his hand!

These pharmaceutical companies are certainly not stupid.

They just wanted to get the latest third-generation sequencing information from Chen Nan.

For these large international pharmaceutical companies, the first opportunity represents the future market share!

However, Chen Nan pretended to be confused and pretended not to understand.

And when the representatives of the pharmaceutical company left.

Only now did Yuan Chaomin have time to eat. Looking at the resplendent and magnificent private room, he said with some emotion: "It's unbelievable..."

"All of this... is true!"

"How can we be so popular?"

Lu Shouyue smiled wryly: "That's the truth."

And Yang Fupeng on the side is the most lying and winning.

When he learned that Yang Fupeng was brought by Chen Nan, he was not eligible to donate medicine.

But he gained the qualification second only to Chen Nan!

After saying this, Yang Fupeng felt like he was dreaming.

Damn it!

The feeling of hugging the thigh is really comfortable.

More hugs in the future...

Yuan Chaomin suddenly lowered his voice at this time, and said to Chen Nan:

"Professor Chen, do you really... understand that?"

Chen Nan was taken aback: "What?"

Yuan Chaomin was tickled by Chen Nan: "That's it!"

"The one you said! Three generations!"

"Three generations!"

Chen Nan smiled: "Secret!"

Immediately, Yuan Chaomin lost his anger and started to eat angrily.

The meals are delicious!

He eats very fast.

However, he soon discovered that eating fast is a good thing.

Because soon, an endless stream of experts came to talk to Chen Nan and left their contact information...

Chen Nan didn't refuse either.

However, when he saw those experts who would rather not attend the meeting for him, and those experts who helped him speak.

In the remarks column, there is a special symbol.

Wait until the luncheon is over.

Yuan Chaomin and others were about to return to the hotel.

Chen Nan was personally invited by Drizzt to chat in the room.

Straight to the point, Drizzt directly took out an invitation letter!

"Professor Chen, I would like to invite you to join the World Cancer Society!"

"However, according to our rules, there is no way for you to be directly elected to the council."

"So, we can only give you a membership invitation letter."

"At the same time, he was awarded the title of Honorary Director of the China Region."

"Our Tumor Association needs talents like you."

Chen Nan was stunned for a moment!

"Is this... suitable?"

Drizzt smiled slightly: "We, the World Cancer Society, serve patients, and ability is the only criterion for testing!"

"And you, have such ability!"

Chen Nan smiled and did not refuse.

And after the two chatted a lot, Drizzt still couldn't hold back his inner curiosity, and asked, "Director Chen, the third-generation sequencing...do you really have a clue?"

Chen Nan looked at Drizzt, nodded and smiled slightly.

Then he turned and left!

Leaving Drizzt standing in the room, he didn't turn around for a long time!

really have? !

real!

Drizzt was very excited.

...

...

End of the meeting,

The last day is still a pharmaceutical company entertainment event.

As for Shen Guzhang, here he saw his son after the operation.

He looked at Shen Yuzhe lying on the bed, staring blankly out of the window, feeling extremely distressed!

This blow was too serious for Shen Yuzhe.

The operation was a success!

Eighty percent of Shen Yuzhe's tongue was removed.

Although tongue reconstruction surgery was performed, but... a prosthesis is a prosthesis after all.

from now on!

The delicacy of the world has nothing to do with him.

Ups and downs, from now on farewell.

Even talking...

have become very difficult.

all of these!

For Shen Yuzhe, it was a big blow.

Shen Guzhang was about to speak when he suddenly saw a newspaper in Shen Yuzhe's hand!

"Rochester Special"

This is a very famous local media.

And the key!

On the cover, there is a young man, imposing, with sharp eyes and full of confidence!

But the title is like this!

"The Mysterious TCM Genius from the East, a Blockbuster at the World Cancer New Drug Conference! "

Such a headline, in China, is absolutely impossible for even the UC editorial department to report it.

But!

In the United States, it has attracted a lot of attention.

Chen Nan's demeanor at this meeting was immediately known to many people in the United States.

When Shen Guzhang saw this scene, he was extremely angry in his heart!

He quickly picked up the newspaper and was about to throw it away.

But was suddenly grabbed by Shen Yuzhe.

"Son, don't worry!"

"There is a father!"

"don’t worry!"

"This grudge, I remember..."

Shen Yuzhe's eyes were empty, as if he had lost his soul.

And he turned around slowly, looked at Shen Guzhang, tears streaming down his face.

He has too many grievances to vent.

Originally, I thought that coming to the United States this time would be a good way to deflate Chen Nan.

But, who would have thought?

However, Chen Nana attended the meeting, and at the meeting site, let Geoffrey lose to Maicheng, and the stock price was low. Facing NMPA's doubts, he was even more angry at the other party, causing the other party to fall into a stalemate.

The key point is that the new drug he came up with, Acoladin, became a blockbuster.

It even brought out some information from the third-generation sequencing, which attracted everyone.

If one were to say who is the most dazzling person at this year's new drug launch conference, it would be Chen Nan!

the next day!

Award ceremony!

Sure enough, not everyone expected.

Chen Nan won the honor of this year's most anticipated new drug award.

This title is equivalent to this year's best performance award.

However, no one doubted or questioned Chen Nan's award.

Now, many people are guessing, Chen Nan really mastered the third-generation sequencing technology?

Not only them!

Even in China at this time.

Qin Shiming and others urgently held a meeting to discuss the third-generation sequencing technology.

Because it started yesterday!

Qin Shiming received no less than fifty calls one after another.

All come from major pharmaceutical companies, as well as some cooperative countries and friendly academic exchange countries.

There is only one problem for them!

That's the problem with three-generation sequencing.

This question stunned Qin Shiming.

Even a little unclear what is going on?

until later!

Only then did he know the truth.

Qin Shiming was also a little confused.

Chen Nan really mastered the third-generation sequencing technology?

If this is true?

This is great!

Thinking of this, Qin Shiming quickly called Chen Nan!

Asked straight to the point:

"Xiao Chen, do you understand three-generation sequencing?"

Chen Nan responded tactfully: "Well, understand a little bit!"

Qin Shiming, who heard Chen Nan's reply with his own ears, suddenly became excited.

"good!"

"OK!"

"This is a big deal!"

But what Chen Nan said next made Qin Shiming stunned.

"But... Mr. Qin, this technique is not mine."

"It's one of my partners."

"The other party is a research institute opened in the United States. For the third-generation sequencing, the research was relatively early, and now it has achieved results."

"But... I don't have enough right to speak."

Chen Nan's words made Qin Shiming stunned and even disappointed.

actually!

There is a reason why Chen Nan said that.

The new drug Acradine some time ago can attract the attention of those crazy bees and butterflies.

Even unscrupulous start!

He didn't even dare to imagine that if this technology was used, would there be a stronger force to make a move?

Chen Nan is patriotic!

I also want to contribute to the country.

However, he wanted to ensure his own safety first, and he hoped that he could have a bargaining chip in his hand.

Moreover, as a genetic testing company, he can openly discuss cooperation with the country.

Huaran, if the operation is better.

It will even become a trump card in Chen Nan's hand!

That's why he made these remarks.

"Can you get in touch with him?"

Chen Nan nodded: "Yes!"

After Qin Shiming listened to it, he became excited.

"good!"

"OK!"

"By the way, Xiao Chen, congratulations on winning the honor of the most anticipated new drug."

"Come back, I'll throw a celebration banquet for you!"

Chen Nan smiled and nodded: "Thank you, Director."

...

the next day.

Chen Nan was preparing to return home, but received a special invitation.

The inviter is Dane's teacher.

Chief Oncologist at the Mayo Clinic in Rochester.

Mr. Nelson!

This person is also the vice president of the World Cancer Society.

Chen Nan looked at the time, he was on an evening flight in the afternoon, so he was not in a hurry.

The other party's invitation was for Chen Nan to help diagnose and treat a patient.

Chen Nan was personally invited by Dane.

To this, Chen Nan did not refuse,

"Okay, just pick me up tomorrow."

Dane smiled gratefully when he heard the sound: "Thank you, Professor Chen."

"Also, congratulations on joining the World Cancer Society."

Chen Nan couldn't help smiling, and smiled.

"What's the point of congratulations?"

"Professor Dane is already a member of the association."

Dane shook his head: "No, there is a big difference."

"The Tumor Association, invited by the president, has a high gold content."

At this time, Chen Nan asked curiously: "By the way, who is the patient?"

Dane suddenly said, "Chinese-American."

"The old man is very old."

"Professor Nelson would like your help."

Chen Nan became even more curious.

...

ps: Thanks to the leader of "Wishing Thousands of Cities Mobai" for his heroic reward of 100,000, becoming the 20th leader of this book, sincere thanks!