Ask Sword

In the classroom of the Supervisory Building of the Academy, Yang Yu raised his hand and asked, "Doctor, why didn't Li Ang come to class?"

"He's doing a very important study."

Ph.D. Chao Wenyuan said with a stern face: "Not only today's class, but you won't be able to see him for a while."

"ah?"

Yang Yu and the others were astonished, and subconsciously asked, "What kind of research would take so long? How could Jijiu agree to grant such a long leave?"

"It's not arithmetic anyway!"

Chao Wenyuan patted down the table, blew his beard and stared, muttering something in his mouth, "It's a waste of money for such a good seed not to study arithmetic."

————

Outside the Patent Office of the Academy, Hu merchants and Jing country merchants in gorgeous silk costumes were holding stacks of flying money banknotes, and surrounded Su Feng, a doctor of science.

"Dr. Su Feng, where is Mr. Li Xiaolang? Didn't you say that you can see him in a few days?"

"Yes, Dr. Su Feng, we have all the money ready. Just wait for his permission, and we will ship the goods back."

"Doctor, our caravan eats horse chews in Chang'an City, and it costs money every day. I really can't afford to wait. Please ask Mr. Li Xiaolang, please."

The big stacks of flying money waved by the businessmen made the apprentices in the patent office dizzy,

But Su Feng had no choice but to let go of the monk's aura, and slightly shocked the crowd, "I'm really sorry, I can't help with this. Li Ang is very busy at this time, and I don't see outsiders, everyone should go home and wait for the notice."

————

In the north of Chang'an City, Daming Palace, Hanxiang Hall.

"The little doctor Li didn't come? Didn't you tell him that it was for the emperor's heir?"

Concubine Zheng Gui, who was born in Qiwang with five surnames, sat on a bench, stroking her pregnant belly in October, and sternly scolded the servant kneeling in the hall.

"Sister, don't be angry, it's not good for the emperor's heir."

Another concubine Lu, who was also from Qiwang of the five surnames, comforted her softly, looked at the servant and said, "Go to the academy again and say that the imperial doctor said that the delivery date is only a few days away. Please, Mrs. Li, The doctor came to Daming Palace every day after returning home from school.

Don't delay anything,

When the emperor's heir is born safely, the Zheng family will remember his kindness."

As the concubine surnamed Lu was talking, she suddenly noticed the frightened expression on the eunuch's face, paused, and said hesitantly: "Did you not see that little doctor Li, or did the academy simply not let you in? Who came forward to stop you?" ?”

"It's sacrificial wine."

The eunuch lowered his head and said in a trembling voice, "Let me bring a sentence to the two imperial concubines for the sacrificial wine."

The two noble concubines stood up together, "What are you talking about?"

"Everyone, be quiet."

————

In the afternoon, Chai Cuiqiao, who was picked up at the foot of the back mountain by the school carriage, jumped out of the carriage carrying the large and small packages.

"Master."

Chai Cuiqiao, who didn't know why, glanced at the carriage that was quietly driving away, turned her head to look at Li Ang who was standing at the intersection, and said doubtfully, "This is us."

"In the next few days, we will live in the academy."

Li Ang smiled apologetically, took the package in Chai Cuiqiao's hand, and led her to an unnamed pavilion at the foot of the back mountain.

There are a variety of experimental equipment on the first floor of the pavilion, and the second floor is the bedroom residence.

Xuegong attaches great importance to blood carbuncle drugs,

Jijiu, who got the news, applied to the head of the mountain to provide Li Ang with an entire pavilion as an experiment site, and granted a long vacation at one time, and he would not lose credits if he did not take courses such as Yulu and National History.

"What's this?"

Chai Cuiqiao, who put down the change of clothes and toiletries, poked the flask on the table curiously.

"This is the distillation flask, this is the condenser tube, this is the vacuum introduction tube, this is the receiving flask, and this is the capillary tube."

Li Ang introduced the experimental instruments to Chai Cuiqiao like a few treasures. These things were all made of hot glass by the monks in the academy using their thoughts.

"What about this one?"

Chai Cuiqiao pointed to a huge metal device with a cylindrical structure next to the wooden table.

"Simple circulating water vacuum pump."

Li Ang said with a smile: "The impeller rotor is eccentrically installed in the cylindrical pump casing, and the blades of the rotor are inclined forward.

The pump body is filled with an appropriate amount of water as the working fluid. When the impeller rotor rotates, the working water will form a water ring that swirls along the pump casing under centrifugal action.

There is a certain space between the closed rotating water ring and the impeller rotor, and the air can be pumped out when it rotates repeatedly.

Due to the poor conditions, I can only let the academic doctors design it in the form of human rotation.

The faster it turns, the more efficiently it pumps air. "

"Well"

Chai Chai blinked, "What is the function of this pump?"

"Reduce the pressure and even create a vacuum."

Li Ang waved his hand and said casually: "Of course, in this experiment, its main function is to carry out vacuum distillation.

And something distilled?"

Li Ang brought up a large bag of things from under the table and threw it on the table.

"This is."

Chai Chai asked in surprise, "Garlic?"

"That's right."

Li Ang smiled and said, "The antibacterial ingredients that can solve blood carbuncle, or infection and inflammation, are in the garlic."

Diallylthiosulfinate, or allicin, is an organosulfur compound.

It is not an antibiotic, but a broad-spectrum antimicrobial.

It has inhibitory and killing effects on a variety of cocci, pertussis bacillus, diphtheria bacillus, Shigella, typhoid and paratyphoid bacillus, tubercle bacillus, etc.

It can even deal with a variety of fungi, viruses, and even amoebas that can cause meningoencephalitis and keratitis, and pinworms that live in the intestines.

Allicin can be used both internally and externally, with less side effects, and it is not easy to cause the corresponding fungi or bacteria to develop drug resistance - because its bactericidal mechanism is mainly to directly destroy enzymes containing thiol groups.

It is extremely difficult for fungi and bacteria to mutate and crack.

And the most common pyogenic coccus, Staphylococcus, happens to be within the killing range of allicin.

Considering the relatively difficult preparation of another antibiotic—penicillin, allicin can be said to be the most readily available antibacterial drug at this stage.

The only question is how to get it.

There is no allicin in fresh garlic, but only alliin. When the garlic is cut or crushed, alliinase is activated to catalyze the decomposition of alliin into allicin.

And raw garlic, calculated according to the effective dose, at least a few kilograms to a dozen kilograms at a time.

It must be purified.

For the next few days, Li Ang and Chai Cuiqiao stayed in the pavilion, busy using various methods to extract allicin.

After experiments, there are two most feasible methods for extracting allicin at this stage.

One, steam vacuum distillation method.

First peel and wash the garlic, put it in a stone mortar and mash it, pour it into a glass container, pour in distilled water and cover it tightly,

Slightly heated in a salt bath to make it enzymatically hydrolyzed,

Then use the circulating water vacuum pump to carry out steam vacuum distillation,

After collecting the distillate, it was distilled again under reduced pressure.

Circulate several times, and after getting the solution, put it in a simple refrigerator made of ice trays for storage—allicin is extremely unstable, and it loses its antibacterial activity when it encounters heat or alkali, and the validity period is very short at room temperature.

Coupled with the strong and touching taste and other reasons, it has not been able to compete with other antibacterial drugs in the memory of the foreign world.

Second, ethanol extraction method.

Also peel the garlic, wash it, mash it, enzymolyze it with slight heat, pour in different concentrations of ethanol, use a reflux tower to fully dissolve the allicin in the ethanol, wait for several hours, and turn the garlic paste at a speed of more than 1,000 revolutions per minute. Centrifuge at high speed, filter with double-layer rice paper, discard garlic residue,

The filtrate was distilled under reduced pressure and repeated several times to obtain a solution.

The entire extraction process lasted several days,

The master and servant, who were physically and mentally exhausted, finally smiled when they looked at the hundreds of test tubes on the table containing the light yellow oily liquid allicin.

Condenser tube technology has been used similarly in Xuegong distilled liquor before that,

The treatment of garlic can also be supported by evidence from previous medical books.

The only problem is that it stinks, the process of extracting the allicin is literally stinks.

It's almost like having a food seminar between canned herring, stinky tofu, and kiviak (the Eskimo food made from rotting petrel seals).

Inexplicably, Li Ang recalled the sour smell of celiac disease lesions in general surgery, and wondered if he was a surgeon specializing in the abdominal cavity in another world.

Even if the windows are fully opened and the breeze talisman is used to ventilate at all times, both master and servant feel that they can't stand it.

"Master, I smell so bad."

Chai Chai sniffed his clothes and said with a sad face.

"It's okay, I stink too."

Li Ang comforted him, and asked Chai Chai to go back to Jinchengfang to wash and rest, while he stepped out of the pavilion with a box of test tubes.